Table 4

Performance data of QStatin risk scores

QRESEARCH (Internal validation)THIN (external validation)
Multiple imputation (m=10)Complete case
WomenMenWomenMenWomenMen
Acute renal failure
R2 (95% CI)62.86 (60.06 to 65.66)58.50 (55.64 to 61.37)59.28 (57.23 to 61.34)59.90 (58.08 to 61.72)60.08 (57.68 to 62.48)57.77 (55.52 to 60.02)
D statistic (95% CI)2.66 (2.50 to 2.82)2.43 (2.29 to 2.57)2.47 (2.36 to 2.58)2.50 (2.40 to 2.60)2.51 (2.38 to 2.64)2.39 (2.28 to 2.51)
 AUROC (95% CI)0.8520.8340.8420.8500.8450.839
Cataract
R2 (95% CI)58.70 (58.06 to 59.34)60.55 (58.76 to 62.34)58.85 (58.33 to 59.37)59.67 (59.04 to 60.29)59.10 (58.50 to 59.69)58.02 (57.27 to 58.77)
D statistic (95% CI)2.44 (2.41 to 2.47)2.54 (2.44 to 2.63)2.45 (2.42 to 2.47)2.49 (2.46 to 2.52)2.46 (2.43 to 2.49)2.46 (2.37 to 2.44)
 AUROC (95% CI)0.8800.8810.8710.8680.8740.862
Liver dysfunction
R2 (95% CI)17.20 (15.38 to 19.02)13.73 (11.75 to 15.72)15.57 (14.32 to 16.79)10.91 (9.83 to 12.00)15.55 (14.16 to 16.94)9.84 (8.68 to 11.00)
D statistic (95% CI)0.93 (0.87 to 0.99)0.82 (0.75 to 0.89)0.88 (0.84 to 0.92)0.72 (0.68 to 0.76)0.88 (0.83 to 0.92)0.68 (0.63 to 0.72)
 AUROC (95% CI)0.6600.6350.6380.6010.6330.589
Myopathy
R2 (95% CI)40.98 (40.95 to 41.01)38.05 (38.02 to 38.08)42.17 (38.24 to 46.10)37.86 (34.49 to 41.24)42.11 (37.46 to 46.76)38.26 (34.15 to 42.37)
D statistic (95% CI)1.71 (1.61 to 1.81)1.60 (1.51 to 1.69)1.75 (1.60 to 1.89)1.60 (1.48 to 1.71)1.75 (1.57 to 1.92)1.61 (1.47 to 1.75)
 AUROC (95% CI)0.7270.7430.7630.7270.7610.727
  • AUROC, area under receiver operating characteristic curve.