Author (year) | Cohort | Study design | N | Population | Age (years) (mean (SD)) | % Men | FU (years) | End points (No of events with AAC/without AAC/total) | Adjusted for |
Witteman (1986)28 | EPOZ Study | Nested case control | 415 | General | 68.2 (ns) | 46 | 6 to 9 | CVM (ns/ns/83) | Age, SBP, DBP Tl, BMI, smk, DM |
Wilson (2001)27 | Framingham Heart Study | Cohort study | 2515 | General | 60.7 (8.0) | 41.8 | 22 | CVE (ns/ns/709) | Age, smk, DM, SBP, LVH, BMI, Tcl, HDL |
CAD (ns/ns/454) | |||||||||
CVM (ns/ns/365) | |||||||||
Levitzky (2008)19 | Framingham Heart Study | Cohort study | 2149 | General | 60.0 (8.0) | 39.5 | 32 | CVE (ns/ns/1121) | Age, smk, DM, SBP, LVH, BMI, Tcl, HDL |
CAD (ns/ns/702) | |||||||||
CVD (ns/ns/201) | |||||||||
Hollander (2003)17 | Rotterdam Study | Cohort study | 5631 | General | 69.5 (9.2) | 39.7 | 6.1 | CVD (138/24/162) | Age, gender, DM, smk, SBP, DBP, Tcl, HDL, CVD |
van der Meer (2004)31 | Rotterdam Study | Cohort study | 6389 | General | 69.3 (9.2) | 39.1 | 7 to 10 | CAD (ns/ns/258) | Age, gender, DM, smk, SBP, DBP, Tcl, HDL, BMI, aspirin use |
Rodondi (2007)23 | SOF Study | Cohort study | 2056 | Women >65 y | 72.0 (5.0) | 0 | 13 | CVM (256/65 / 321) | Age, smk, DM, SBP, physical activity, waist Ø, CAD, MI |
Shousboe (2008)24 | Clodronate British Study | Nested case control | 732 | Women >75 y | 80.1 (4.1) | 0 | 4 | CVE (ns/ns/408) | Age, SBP, LDL, HDL, Tgl, smk, RF, EQV, DM, HT, CAD, CVD |
CAD (ns/ns/191) | |||||||||
CVD (ns/ns/178) | |||||||||
Bolland 1 (2010)12 | ns | Cohort study | 1471 | Women >55 y | 74.2 (4.1) | 0 | 4.4 | CVE (67/38/105) | Age, SBP, smk, DM, HT, BMI |
CAD (34/15/49) | |||||||||
CVD (35/22/57) | |||||||||
Bolland 2 (2010)12 | ns | Cohort study | 323 | Men >40 y | 57.2 (10.1) | 100 | 3.3 | CAD (3/3/6) | Age, SBP, smk, DM, HT, Tcl |
Golestani (2010)15 | ns | Nested case control | 489 | General | 69 (10.0) | 37.2 | 2.8 | CVE (19/5/24) | Age, gender, HT, Tcl, DM, smk, family history of CAD |
AAC, abdominal aortic calcification; BMI, body mass index; CAD, coronary artery disease; CVD, cerebrovascular disease; CVE, cardiovascular events; CVM, cardiovascular mortality; DBP, diastolic blood pressure; DM, diabetes mellitus; FU, follow-up; EQV, EuroQolVAS score; HDL, high density lipoprotein cholesterol; HT, hypertension; LDL, low density lipoprotein cholesterol; LVH, left ventricular hypertrophy; MI, myocardial infarction; ns, not stated; RF, renal insufficiency; SBP, systolic blood pressure; smk, smoking; Tcl, total cholesterol; Tgl, triglycerides.