Table 1

Characteristics of studies examining cognitive function in patients with coronary artery disease

Study	Sample	Age (M ± SD)	Analysis	Cognitive functions	Results	NOS
Case–control studies
Selnes et al,13 2009	152 on-pump CABG pts 75 off-pump CABG pts 99 CAD pts 69 controls	63.6±9.4 66.0±10.5 65.7±9.2 62.5±10.9	Linear mixed models	Attention Executive function Language Motor speed Psychomotor speed Verbal memory Visuoconstruction Visuospatial memory	CAD groups < controls baseline: motor speed, psychomotor speed, global cognition (composite) after 72 months: executive function, visuoconstruction, visuospatial memory, global cognition (composite)	7
Silbert et al,14 2007	349 CABG pts 170 controls	67.9±7.7 68.5±6.4	Unpaired t tests	Executive function^* Motor speed Psychomotor speed Verbal fluency Verbal memory	CABG pts < controls all tests, except motor speed	5
Cohort studies
Arntzen et al,15 2011	5033 stroke-free adults	58.8±9.2 (m) 58.2±9.7 (w)	Logistic regression analysis	Motor speed Psychomotor speed Verbal memory	No association	6
Roberts et al,16 2010	1969 older adults	80.4	Logistic regression analysis	Executive function Language Memory Visuospatial skills	CAD associated with: na-MCI, not a-MCI	8
Singh-Manoux et al,17 2008	5837 civil servants	61.0	ANCOVA	Abstract reasoning Global cognition Verbal fluency Verbal memory Vocabulary	CAD associated with: all: abstract reasoning, global cognition, vocabulary w: verbal fluency	8
Verhaegen et al,18 2003	516 older adults	84.9±8.7	Hierarchical regression analysis	Knowledge Perceptual speed Verbal fluency Verbal memory	CAD associated with: verbal fluency, global cognition (composite)	8

↵* Executive function test measuring cognitive flexibility.
a, amnestic; ANCOVA, analysis of covariance; CABG, coronary artery disease bypass graft; CAD, coronary artery disease; m, men; MCI, mild cognitive impairment; na, non-amnestic; NOS, Newcastle-Ottawa quality assessment Scale rating; w, women.