Table 1

Patient characteristics, comorbid conditions, and echocardiographic parameters

Combined AS and AR (n=74)Isolated AS (n=232)p Value
Age, years, mean ± SD70±1173±110.11
Female, n (%)43 (58)141 (61)0.68
Body surface area, m2 1.52±0.181.52±0.170.96
NYHA functional class, n (%)
 I33 (45)111 (48)0.63
 II31 (42)90 (39)0.64
 III or IV10 (14)29 (13)0.82
Comorbidities, n (%)
 Hypertension35 (47)131 (56)0.17
 Diabetes mellitus16 (22)53 (23)0.83
 Dyslipidaemia10 (27)68 (25)0.82
 Atrial fibrillation19 (26)51 (22)0.51
 Ischaemic heart disease20 (27)63 (27)0.98
 Prior cerebral infarction6 (8)31 (13)0.21
 Haemodialysis9 (12)22 (9)0.51
Echocardiographic indices
 LV ejection fraction, %60±1063±110.09
 LV end-diastolic dimension, mm47±743±6<0.001
 LV end-systolic dimension, mm30±827±70.001
 Aotic valve area, cm2 0.80±0.200.79±0.180.87
 Aortic valve area index, cm2/m2 0.54±0.150.53±0.120.56
 Aortic jet velocity, m/s4.3±0.94.0±0.70.003
 Mean aortic gradient, mm Hg46±1939±150.001
  • AS, aortic stenosis; AR, aortic regurgitation; LV, left ventricular.