Pre- and postnatal diagnosis of congenital heart defects not associated with chromosomal anomalies: the EPICARD study
| ACC-CHD categories | N | Prenatal diagnosis | Postnatal diagnosis | Postmortem diagnosis | ||||
| % | 95% CI | ≤7 days | 8–28 days | 29 days–3 months | 3 months–1 year | |||
| % | % | % | % | % | ||||
| 1. Heterotaxy, including isomerism and mirror-imagery | 37 | 89.2 | 74.6 to 97.0 | 8.1 | 0.0 | 2.7 | 0.0 | 0.0 |
| 2. Anomalies of the venous return | 25 | 16.0 | 4.5 to 36.1 | 32.0 | 16.0 | 28.0 | 4.0 | 4.0 |
| 3. Anomalies of the atria and interatrial communications | 164 | 4.3 | 1.7 to 8.6 | 29.3 | 26.8 | 26.8 | 11.6 | 1.2 |
| 4. Anomalies of the atrioventricular junctions and valves | 91 | 67.0 | 56.4 to 76.5 | 19.8 | 3.3 | 2.2 | 2.2 | 5.5 |
| 5. Complex anomalies of atrioventricular connections | 13 | 100.0 | 75.3 to 1.0* | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 6. Functionally univentricular hearts | 133 | 92.5 | 86.7 to 96.3 | 6.0 | 0.7 | 0.0 | 0.0 | 0.7 |
| 7. Ventricular septal defects (VSD) | 1353 | 9.6 | 8.1 to 11.3 | 67.4 | 9.0 | 9.8 | 3.8 | 0.4 |
| 8. Anomalies of the ventricular outflow tracts (ventriculoarterial connections) | 503 | 39.2 | 34.9 to 43.6 | 29.6 | 7.1 | 14.5 | 5.4 | 4.2 |
| 9. Anomalies of the extrapericardial arterial trunks | 143 | 44.7 | 36.4 to 53.3 | 28.7 | 9.8 | 10.5 | 2.1 | 4.2 |
| 10. Congenital anomalies of the coronary arteries | 9 | 0.0 | 0.0 to 33.6* | 0.0 | 0.0 | 44.4 | 55.6 | 0.0 |
| All, excluding cases with chromosomal anomalies | 2471 | 25.6 | 23.9 to 27.3 | 48.0 | 9.1 | 11.2 | 4.4 | 1.7 |
| All, excluding cases with chromosomal anomalies or genetic syndromes | 2387 | 24.8 | 23.1 to 26.6 | 48.8 | 9.0 | 11.5 | 4.5 | 1.4 |
| All, excluding cases with chromosomal, genetic syndromes or other anomalies | 2036 | 23.1 | 21.2 to 24.9 | 50.9 | 9.4 | 11.8 | 4.5 | 0.3 |
| All, excluding cases with chromosomal or other anomalies and IVSD* | 930 | 40.2 | 37.0 to 43.4 | 28.6 | 10.4 | 14.4 | 5.6 | 0.8 |
↵* One-sided CI.
IVSD, isolated ventricular septal defects.