Table 1

Frequency of comorbidities in total atrial fibrillation patient population and among those treated with warfarin

60–69 years70–79 years80+ years (reference group)
Age groupAll patients n (%)Patients n (%)Patients treated with warfarin n (%)χ2 Value*p Value*Patients n (%)Patients treated with warfarin n (%)χ2 Value†p Value†Patients n (%)Patients treated with warfarin n (%)
Number of patients81 38117 0549648 (57)2883<0.000130 35016 641 (55)3453<0.000133 97710 830 (32)
Women42 318 (52)6300 (37)3268 (52)1094<0.000114 315 (47)7433 (52)1849<0.000121 300 (63)6246 (29)
Men39 063 (48)10 754 (63)6380 (59)1254<0.000116 035 (53)9208 (57)1283<0.000112 677 (37)4584 (36)
BMI, mean (SD)27.1 (5.2)29.0 (5.9)29.5 (6.1)27.6 (5.2)28.0 (5.2)25.8 (4.7)26.5 (4.6)
% with non-missing BMI858774877482
Hypertension (diagnosed)44 841 (55)8362 (49)4951 (59)1461<0.000117 328 (57)9692 (56)1694<0.000119 151 (56)6603 (34)
Diabetes10 022 (12)2233 (13)1333 (60)377<0.00014291 (14)2358 (55)355<0.00013498 (10)1175 (34)
LVEF <40%2719 (3)723 (4)529 (73)109<0.00011165 (4)797 (68)92<0.0001831 (2)391 (47)
Coronary heart disease19 860 (2)3531 (2)2088 (59)588<0.00018052 (27)4592 (57)794<0.00018277 (24)2901 (35)
Congestive heart failure21 075 (26)3094 (18)2152 (70)1277<0.00017401 (24)4490 (61)1296<0.000110 580 (31)3549 (34)
Stroke8142 (10)1264 (7)807 (64)369<0.00013084 (10)1760 (57)394<0.00013794 (11)1259 (33)
Stroke/TIA10 763 (13)1567 (9)1029 (66)496<0.00013928 (13)2299 (59)543<0.00015268 (16)1797 (34)
Alzheimer's/dementia5382 (7)187 (1)95 (51)121<0.00011519 (5)617 (41)294<0.00013676 (11)664 (18)
Thromboembolism‡4619 (6)803 (5)554 (69)132<0.00011729 (6)1109 (64)137<0.00012087 (6)943 (45)
Vascular disease‡12 389 (15)2 225 (13)1353 (61)418<0.00014997 (16)2847 (57)487<0.00015167 (15)1816 (35)
CHADS2 score
 010 241 (13)6243 (37)3072 (49)3998 (13)2038 (51)0 (0)0 (0)
 124 859 (31)6701 (39)3925 (59)1514<0.00019865 (33)5297 (54)1310<0.00018293 (24)2249 (27)
 2+46 281 (57)4110 (24)2651 (65)1458<0.000116 487 (56)9306 (56)2181<0.000125 684 (76)8581 (33)
CHA2DS2 -VASc score
 01620 (2)1620 (9)798 (49)0 (0)0 (0)0 (0)0 (0)
 16276 (8)4348 (25)2292 (53)1928 (6)1028 (53)0 (0)0 (0)
 2+73 485 (90)11 086 (65)6 558 (59)2625<0.000128 422 (94)15 613 (55)3370<0.000133 977 (100)10 830 (32)
HAS-BLED
 0–131 522 (39)10 337 (61)5805 (56)1169<0.000110 445 (34)5857 (56)1167<0.000110 740 (32)3518 (33)
 2+49 859 (61)6717 (39)3843 (57)1478<0.000119 905 (66)10 784 (54)2271<0.000123 237 (68)7312 (31)
  • 2 tests comparing the proportion of patients treated with warfarin in the 60–69 years age group compared with the 80+ years age group.

  • †χ2 tests comparing the proportion of patients treated with warfarin in the 70–79 years age group compared with the 80+ years age group.

  • ‡Diagnostic codes used to define are shown in appendix S1.

  • BMI, body mass index; LVEF, left ventricular ejection fraction; TIA, transient ischemic attack.