Univariate logistic regression analysis of predictors of poor outcome (n=162)
| Predictor | Unadjusted OR | 95% CI | p Value |
|---|---|---|---|
| Clinical characteristic | |||
| Age (years) | 1.02 | 0.95 to 1.07 | 0.52 |
| Parity (number) | 0.89 | 0.65 to 1.13 | 0.38 |
| BMI (kg/cm2) | 0.95 | 0.89 to 1.02 | 0.17 |
| Systolic blood pressure (mm Hg) | 0.97 | 0.95 to 0.99 | 0.02 |
| Heart rate (beats/min) | 1.01 | 0.99 to 1.03 | 0.16 |
| NYHA functional class | 1.43 | 0.85 to 2.43 | 0.18 |
| Medication | |||
| Carvedilol (yes, no) | 0.67 | 0.31 to 1.45 | 0.31 |
| ACE inhibitors (yes, no) | 0.71 | 0.38 to 1.34 | 0.29 |
| Furosemide (yes, no) | 0.81 | 0.24 to 2.78 | 0.74 |
| Digoxin (yes, no) | 1.31 | 0.68 to 2.52 | 0.42 |
| Echocardiography | |||
| LVEDD (mm) | 1.05 | 1.00 to 1.11 | 0.052 |
| LVESD (mm) | 1.07 | 1.02 to 1.12 | 0.009 |
| Ejection fraction (%) | 0.95 | 0.91 to 0.99 | 0.019 |
| E/A | 2.09 | 1.29 to 3.39 | 0.003 |
| Deceleration time (ms) | 0.99 | 0.99 to 1.01 | 0.09 |
| LV thrombus | 0.97 | 0.37 to 2.53 | 0.95 |
| Laboratory | |||
| Haemoglobin (g/dl) | 0.86 | 0.12 to 1.05 | 0.15 |
| Creatinine (mmol/l) | 1.01 | 0.99 to 1.03 | 0.35 |
| Urea (mmol/l) | 1.09 | 0.95 to 1.25 | 0.22 |
| Total protein (g/l) | 0.99 | 0.96 to 1.02 | 0.37 |
| Albumin (g/l) | 0.99 | 0.96 to 1.02 | 0.35 |
| Total bilirubin (μmol/l) | 1.01 | 0.99 to 1.03 | 0.29 |
| Direct bilirubin (μmol/l) | 1.01 | 0.99 to 1.04 | 0.37 |
| Indirect bilirubin (μmol/l) | 1.03 | 0.99 to 1.08 | 0.30 |
| Alkaline phosphatase (U/l) | 0.99 | 0.99 to 1.00 | 0.28 |
| AST (U/l) | 1.01 | 1.00 to 1.02 | 0.033 |
| ALT (U/l) | 1.01 | 1.00 to 1.02 | 0.03 |
| GGT (U/l) | 1.00 | 0.99 to 1.01 | 0.73 |
| Total cholesterol (mmol/l) | 0.53 | 0.36 to 0.77 | 0.001 |
Stepwise multiple logistic regression analysis revealed that, after adjustment for variables including age, systolic blood pressure, medications, LVEF and NYHA functional class, increased LVESD, lower BMI and lower total cholesterol at baseline were independent predictors of the prespecified poor outcome (adjusted OR 1.09, 95% CI 1.04 to 1.15, p=0.001; OR 0.89, 95% CI 0.83 to 0.96, p=0.004; and OR 0.50, 95% CI 0.34 to 0.73, p=0.0004, respectively).
ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; GGT, γ-glutamyl transpeptidase; LV, left ventricular; LVEDD, LV end diastolic diameter; LVESD, LV end systolic diameter; NYHA, New York Heart Association.