Characteristics of the total cohort, stable chronic obstructive pulmonary disease patients and references
| Covariate | Total | Cases | References | p Value |
|---|---|---|---|---|
| Total, n | 212 | 101 | 111 | <0.001 |
| hs-cTnT, ≥3 ng/l, n (%) | 145 (68.4) | 87 (86.1) | 58 (52.3) | <0.001 |
| hs-cTnT, geometric mean | 4.72 | 7.75 | 3.01 | <0.001 |
| Demographic data | ||||
| Age, years mean (SD) | 59 (10.0) | 64 (7.5) | 54 (9.7) | <0.001 |
| Female, n (%) | 104 (49.1) | 51 (50.5) | 53 (47.7) | 0.689 |
| BMI, kg/m2 mean (SD) | 25.6 (4.6) | 25.1 (4.9) | 26.1 (4.4) | 0.102 |
| Smoking habit | ||||
| Pack-years, mean (SD) | 21.3 (20.8) | 36.6 (17.6) | 7.3 (11.6) | <0.001 |
| Current smoker, n (%) | 47 (22.2) | 27 (26.7) | 20 (18.0) | 0.127 |
| Spirometry | ||||
| FVC, litre mean (SD) | 3.5 (1.4) | 2.7 (1) | 4.3 (1.3) | <0.001 |
| FEV1, litre mean (SD) | 2.3 (1.3) | 1.3 (0.6) | 3.2 (1) | <0.001 |
| FEV1/FVC, % mean (SD) | 62.6 (17.5) | 47.4 (12.8) | 76.3 (6.4) | <0.001 |
| FEV1/height2, litre/m2 mean (SD) | 0.8 (0.4) | 0.4 (0.2) | 1.1 (0.2) | <0.001 |
| Clinical data | ||||
| Syst BP, mm Hg mean (SD) | 136.4 (20) | 137.8 (21.4) | 135.3 (18.7) | 0.360 |
| Arterial HT, n (%) | 48 (22.6) | 35 (34.7) | 13 (11.7) | <0.001 |
| Diabetes mellitus, n (%) | 8 (3.8) | 3 (3.0) | 5 (4.5) | 0.558 |
| Statin, n (%) | 20 (9.4) | 10 (9.9) | 10 (9) | 0.824 |
| Laboratory data | ||||
| Haemoglobin, g/dl mean (SD) | 14.3 (1.2) | 13.8 (1.1) | 14.8 (1.1) | <0.001 |
| NT-pro BNP, pmol/l, median (IQR) | 7.8 (12.7) | 13.4 (15.1) | 5.5 (7.7) | <0.001 |
| IL6, pg/ml, median (IQR) | 0.8 (2.1) | 2.1 (3.2) | 0.8 (0.9) | 0.016 |
| Neutrophils, 109/l mean (SD) | 3.8 (1.4) | 4.3 (1.5) | 3.3(1.2) | <0.001 |
| Creatinine, mg/dl mean (SD) | 0.8 (0.2) | 0.8 (0.2) | 0.8 (0.1) | 0.331 |
| ECG | ||||
| Heart rate, n/min mean (SD) | 67 (12.0) | 70 (12.4) | 65 (10.5) | 0.005 |
| Pathological Q wave, n (%) | 4 (1.9) | 4 (4) | 0 (0) | 0.034 |
| T wave inversion, n (%) | 7 (3.3) | 3 (3.0) | 4 (3.6) | 0.797 |
| Left ventricular hypertrophy, n (%) | 7 (3.3) | 6 (5.9) | 1 (0.9) | 0.040 |
| Right ventricular hypertrophy, n (%) | 3 (1.4) | 3 (3.0) | 0 (0) | 0.067 |
| P pulmonale, n (%) | 7 (3.3) | 7 (6.9) | 0 (0) | 0.005 |
BMI, body mass index; FEV, forced expiratory volume; FVC, forced vital capacity; HT, hypertension; hs-cTnT, high-sensitivity cardiac troponin T; IL, interleukin; NT-pro BNP, N-terminal probrain natriuretric pepride; one pack-year, 20 cigarettes daily during 1 year, Syst BP: systolic blood pressure.