Hazard ratios (95% CI) for thromboembolism and death according to weekly alcohol intake for men with incident atrial fibrillation
| Alcohol intake, drinks* per week | |||||
|---|---|---|---|---|---|
| Abstainers | <14 (reference) | 14–20 | 21–27 | >27 | |
| Subjects, n | 43 | 1025 | 241 | 234 | 456 |
| Thromboembolism or death | |||||
| VKA adjusted† | 1.82 (1.11 to 2.97) | 1 | 0.92 (0.69 to 1.24) | 1.02 (0.76 to 1.36) | 1.36 (1.11 to 1.66) |
| Multi adjusted‡ | 1.62 (0.99 to 2.66) | 1 | 0.99 (0.74 to 1.32) | 1.11 (0.83 to 1.47) | 1.33 (1.08 to 1.63) |
| Frequency adjusted§ | 1.28 (0.75 to 2.18) | 1 | 0.97 (0.70 to 1.33) | 1.07 (0.77 to 1.47) | 1.26 (0.98 to 1.63) |
| Thromboembolism | |||||
| VKA adjusted | 1.30 (0.47 to 3.56) | 1 | 0.65 (0.36 to 1.20) | 1.03 (0.61 to 1.71) | 0.99 (0.66 to 1.49) |
| Multi adjusted | 1.19 (0.43 to 3.28) | 1 | 0.72 (0.39 to 1.33) | 1.08 (0.65 to 1.80) | 1.02 (0.68 to 1.54) |
| Frequency adjusted | 0.95 (0.32 to 2.79) | 1 | 0.75 (0.39 to 1.44) | 1.10 (0.62 to 1.98) | 1.04 (0.62 to 1.73) |
| Death | |||||
| VKA adjusted | 1.16 (0.64 to 2.12) | 1 | 1.03 (0.72 to 1.47) | 1.03 (0.71 to 1.48) | 1.45 (1.09 to 1.94) |
| Multi adjusted | 1.60 (0.91 to 2.81) | 1 | 1.08 (0.79 to 1.49) | 1.10 (0.80 to 1.52) | 1.51 (1.20 to 1.89) |
| Frequency adjusted | 1.25 (0.69 to 2.29) | 1 | 1.05 (0.74 to 1.49) | 1.04 (0.73 to 1.49) | 1.40 (1.06 to 1.86) |
Thromboembolism: includes ischaemic stroke or peripheral arterial thromboembolism. Measures of association in bold indicate statistical significance.
*One drink equates to 12 g of pure alcohol.
†Calculated using Cox's regression with time since atrial fibrillation diagnosis as underlying time variable and adjusted for VKA treatment.
‡Further adjustment for CHA2DS2-VASc components.
§Also adjusted for frequency of intake (not weekly, non-daily or daily).
VKA, vitamin K antagonist.