Inflammatory response, indices of platelet activation and fibrinolytic function
| Placebo | Etanercept | |||||
|---|---|---|---|---|---|---|
| Pre | Post | p Value | Pre | Post | p Value | |
| Cellular response | ||||||
| Neutrophils×109 cells/l | 7.7±0.6 | 7.2±0.5 | 0.16 | 8.8±0.5 | 7.4±0.5* | 0.02 |
| Lymphocytes×109 cells/l | 2.0±0.1 | 1.9±0.1 | 0.19 | 2.3±0.2 | 2.7±0.26* | 0.001 |
| Monocytes×109 cells/l | 0.7±0.1 | 0.6±0.1 | 0.29 | 0.7±0.1 | 0.7±0.1 | 0.16 |
| Cytokines | ||||||
| Interleukin-6 (pg/ml) | 7.5±1.9 | 5.0±1.3 | 0.13 | 10.6±4.0 | 5.8±2.0* | 0.01 |
| TNF-α (pg/ml) | <0.1 | <0.1 | - | 0.12±0.02 | 254±14* | <0.0001 |
| Platelet activation | ||||||
| Platelet monocyte aggregates (%) | 27.7±4.9 | 33±5.8 | 0.23 | 20.3±2.9 | 30.2±5.2* | 0.02 |
| Platelet surface P-selectin+ (%) | 6.7±0.5 | 6.5±0.7 | 0.76 | 6.2±1.3 | 5.0±0.7 | 0.15 |
| Fibrinolytic function | ||||||
| t-PA activity (IU/ml) | 0.45±0.14 | 0.45±0.10 | 1.00 | 0.77±0.09 | 0.52±0.09* | 0.001 |
| PAI-1 activity (IU/ml) | 1.5 (0.8–2.7) | 0.9 (0.6–2.4) | 0.13 | 0.5 (0.4–0.9) | 1.1 (0.3–1.5) | 0.17 |
Data are expressed as the mean±SE or median (IQR) where appropriate. Statistical analyses compare 24 h with baseline using a paired t test or Mann–Whitney where appropriate.
*p<0.05.
PAI-1, plasminogen activator inhibitor type 1; TNF-α, tumour necrosis factor α.