Table 2

Summary of lipid subfraction values

Baseline value18 month valueSlope (%/month)p Value (within group)p Value (between groups)
Total cholesterol (mmol/L)
 Statins+placebo4.5±1.14.0±0.7−0.6% (0.1)<0.0010.84
 Statins+niacin4.4±0.93.9±0.7−0.6% (0.1)<0.001
LDL (mmol/L)
 Statins+placebo2.4±0.82.0±0.5−0.8% (0.2)<0.0010.14
 Statins+niacin2.3±0.71.8±0.5−1.1% (0.2)<0.001
HDL (mmol/L)
 Statins+placebo1.5±0.41.4±0.4−0.3% (0.1)0.007<0.001
 Statins+niacin1.5±0.41.6±0.40.4% (0.1)<0.001
Triglycerides (mmol/L)
 Statins+placebo1.5±0.91.3±0.6−0.4% (0.3)0.100.03
 Statins+niacin1.5±0.91.0±0.4−1.3% (0.3)<0.001
non-HDL (mmol/L)
 Statins+placebo3.1±1.12.6±0.6−0.7% (0.2)<0.0010.047
 Statins+niacin2.9±0.92.3±0.6−1.2% (0.2)<0.001
TC/HDL ratio
 Statins+placebo3.3±1.23.0±0.7−0.3% (0.1)0.02<0.001
 Statins+niacin3.2±0.92.5±0.5−1.0% (0.1)<0.001
  • Means± SD. LDL denotes low density lipoprotein cholesterol. HDL denotes high density lipoprotein cholesterol. TC denotes total cholesterol. All values log-transformed for analysis of slopes over time; slopes presented as percent change per month.