Sensitivity and specificity of different hs-cTn assays for AMI at respective upper limit stratified by time from symptom onset
| Time from symptom onset (h) | Assay and cut-off | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|
| All patients | hs-cTnT, 14 ng/l | 89.6 (86.4 to 92.3) | 77.7 (75.6 to 79.7) | 52.3 (48.7 to 55.9) | 96.5 (95.4 to 97.4) |
| hs-cTnI, 9 ng/l (S) | 94.1 (90.3 to 96.7) | 71.4 (68.4 to 74.3) | 45.1 (40.7 to 49.6) | 98.0 (96.6 to 98.9) | |
| hs-cTnI, 9 ng/l (B) | 92.1 (87.8 to 95.2) | 75.0 (72.1 to 77.8) | 47.5 (42.8 to 52.3) | 97.5 (96.1 to 98.5) | |
| hs-cTnI, 26.2 ng/l (A) | 77.2 (72.1 to 81.7) | 92.6 (91.0 to 94.0) | 72.1 (66.9 to 76.8) | 94.3 (92.8 to 95.5) | |
| <3 | hs-cTnT, 14 ng/l | 73.8 (64.5 to 81.9) | 84.2 (80.2 to 87.6) | 55.6 (47.1 to 64.0) | 92.3 (89.0 to 94.8) |
| hs-cTnI, 9 ng/l (S) | 93.8 (82.8 to 98.7) | 79.8 (74.1 to 84.8) | 48.9 (38.3 to 59.6) | 98.4 (95.4 to 99.7) | |
| hs-cTnI, 9 ng/l (B) | 88.6 (75.4 to 96.2) | 85.0 (79.6 to 89.4) | 53.4 (41.4 to 65.2) | 97.5 (94.2 to 99.2) | |
| hs-cTnI, 26.2 ng/l (A) | 50.8 (38.2 to 63.2) | 97.9 (95.6 to 99.2) | 85.0 (70.2 to 94.3) | 89.6 (85.7 to 92.7) | |
| ≥3 | hs-cTnT, 14 ng/l | 94.7 (91.7 to 96.8) | 75.6 (73.1 to 78.0) | 51.5(47.5 to 55.5) | 98.1 (97.0 to 98.9) |
| hs-cTnI, 9 ng/l (S) | 94.2 (89.8 to 97.0) | 68.6 (65.1 to 72.0) | 44.3 (39.3 to 49.3) | 98.0 (96.1 to 99.0) | |
| hs-cTnI, 9 ng/l (B) | 92.9 (88.2 to 96.2) | 71.8 (68.3 to 75.1) | 46.3 (41.1 to 51.6) | 97.5 (95.7 to 98.7) | |
| hs-cTnI, 26.2 ng/l (A) | 84.4 (79.3 to 88.7) | 91.0 (89.0 to 92.7) | 70.3 (64.7 to 75.5) | 95.9 (94.4 to 97.1) | |
| <6 | hs-cTnT, 14 ng/l | 83.9 (78.5 to 88.5) | 79.6 (76.8 to 82.3) | 52.1 (46.8 to 57.3) | 94.9 (93.1 to 96.4) |
| hs-cTnI, 9 ng/l (S) | 92.0 (85.3 to 96.3) | 73.6 (69.5 to 77.4) | 44.0 (37.6 to 50.6) | 97.6 (95.5 to 98.9) | |
| hs-cTnI, 9 ng/l (B) | 88.9 (81.4 to 94.1) | 77.2 (73.2 to 80.9) | 46.6 (39.6 to 53.7) | 96.9 (94.6 to 98.4) | |
| hs-cTnI, 26.2 ng/l (A) | 65.3 (56.9 to 73.0) | 94.8 (92.7 to 96.3) | 73.4 (64.9 to 80.9) | 92.5 (90.2 to 94.4) | |
| ≥ 6 | hs-cTnT, 14 ng/l | 95.5 (91.8 to 97.8) | 75.6 (72.4 to 78.6) | 52.5 (47.5 to 57.5) | 98.3 (97.0 to 99.2) |
| hs-cTnI, 9 ng/l (S) | 96.0 (90.8 to 98.7) | 69.0 (64.5 to 73.2) | 46.1 (39.9 to 52.4) | 98.4 (96.3 to 99.5) | |
| hs-cTnI, 9 ng/l (B) | 95.0 (89.4 to 98.1) | 72.6 (68.2 to 76.7) | 48.3 (41.7 to 54.9) | 98.2 (96.1 to 99.3) | |
| hs-cTnI, 26.2 ng/l (A) | 87.4 (81.4 to 92.0) | 90.3 (87.7 to 92.5) | 71.2 (64.5 to 77.3) | 96.3 (94.4 to 97.7) |
Cut-off set at the 99th percentile of a healthy reference population.
(A), Abbott; (B), Beckman Coulter; CI, confidence interval; hs-cTnT, high-sensitivity cardiac troponin T; hs-cTnI, high-sensitivity cardiac troponin I; NPV, negative predictive value; PPV, positive predictive value; (S), Siemens.