Table 2

The format of renal denervation trials and their outcomes

Trial	Treatment			Control
Trial	Device	Office SBP reduction (mm Hg)	ABPM SBP reduction (mm Hg)	Format	Office SBP reduction (mm Hg)	ABPM SBP reduction (mm Hg)
Treatment compared with ineligible patients or treatment failure
Symplicity-HTN 1 calculated68	Symplicity Flex	27		Ineligible patients	−26
Treatment compared with baseline (uncontrolled)
Symplicity-HTN 168	Symplicity Flex	27		Nil
Symplicity-HTN 1 ABPM substudy68	Symplicity Flex		6	Nil
EnligHTN-16	EnligHTN	27	10	Nil
RHAS14	OneShot	42		Nil
REDUCE15	Paradise	32		Nil
Vessix FIM16	Vessix V2	27		Nil
Ahmed et al69	RFA catheter		21	Nil
Dörr et al70	Unknown		26	Nil
Zuern et al71	Symplicity Flex	30	7	Nil
Hering et al72	Symplicity Flex	33	5	Nil
Himmel et al73	Unknown	23		Nil
Mylotte et al74	Unknown	30	23	Nil
Prochnau et al75	RFA catheter		15	Nil
Vase et al76	Symplicity Flex		7	Nil
Verloop et al77	Unknown	23		Nil
Simonetti et al20	Symplicity Flex		13	Nil
Voskuil et al78	Unknown	25		Nil
Witkowski et al79	Symplicity Flex	22	6	Nil
Treatment compared with patients randomised to no treatment (unblinded)
Symplicity HTN-27	Symplicity Flex	33		Randomised	1
Symplicity HTN-2 ABPM substudy	Symplicity Flex		11	Randomised		−3
Pokushalov et al80	RFA catheter	25		Randomised	5
Mahfoud et al81	Symplicity Flex	32		Case-control	5
Mahfoud et al9	Symplicity Flex	27		Case-control	4
Brandt et al82	Symplicity Flex	28		Case-control	2
Treatment compared with patients randomised to no treatment (blinded)
No trials available

Negative values indicate rise in SBP at follow-up.
ABPM,Ambulatory blood pressure monitoring; SBP,systolic blood pressure; RFA radiofrequency ablation.