Clinical, anthropometric and echocardiographic characteristics
| Retrospective cohort (n=2843) | SEAS cohort (n=1525) | |||||
|---|---|---|---|---|---|---|
| Mean | SD | Range | Mean | SD | Range | |
| Age (years) | 73.1 | 10.2 | 21–97 | 67.4 | 9.6 | 28–85 |
| Female (%) | 48 | 39 | ||||
| Height (cm) | 167.4 | 8.9 | 140–198 | 170.5 | 9.2 | 145–199 |
| Weight (kg) | 77.2 | 14.9 | 39–159 | 78.1 | 14.2 | 42–159 |
| Body surface area (m2) | 1.89 | 0.2 | 1.3–2.8 | 1.91 | 0.2 | 1.4–2.9 |
| Body mass index (kg/m2) | 27.5 | 4.5 | 15.6–51.9 | 26.8 | 4.2 | 15.5–51.6 |
| LV end-diastolic diameter (mm) | 47.4 | 5.4 | 28–68 | 50.2 | 6.1 | 26–72 |
| LV end-systolic diameter (mm) | 28.5 | 4.9 | 11–46 | 31.6 | 5.3 | 16–52 |
| Shortening fraction (%) | 40.1 | 6.5 | 30–68 | 37.2 | 5.9 | 20–58 |
| Ejection fraction (Teichholz, %) | 64.8 | 7.6 | 51–91 | 66.4 | 7.5 | 40–88 |
| LVOT diameter (mm) | 20.5 | 2.1 | 14–31 | 21.9 | 2.6 | 14–32 |
| LVOT flow velocity (m/s) | 1.04 | 0.18 | 0.7–1.9 | 0.97 | 0.20 | 0.5–1.8 |
| Jet velocity (m/s) | 4.1 | 0.9 | 2.5–6.7 | 3.1 | 0.5 | 1.7–4.8 |
| Mean pressure gradient (mm Hg) | 40.4 | 17.6 | 10–117 | 22.9 | 8.8 | 6–64 |
| Aortic valve area (cm2) | 0.89 | 0.32 | 0.3–2.3 | 1.28 | 0.46 | 0.4–4.0 |
| Aortic valve area index (cm2/m2) | 0.47 | 0.16 | 0.2–1.1 | 0.67 | 0.23 | 0.2–1.9 |
| Velocity ratio | 0.27 | 0.08 | 0.1–0.5 | 0.34 | 0.10 | 0.1–0.8 |
LVOT, left ventricular outflow tract; SEAS, simvastatin and ezetimibe in aortic stenosis trial.6