Baseline aortic diameters and yearly aortic dilatation rates in patients with BAV, DA, and MFS
| BAV N=353 | DA N=51 | MFS N=50 | p Value | |
|---|---|---|---|---|
| Age, year | 48±15 | 71±11 | 35±11 | <0.0001 |
| Gender, male n (%) | 254 (72%) | 40 (78%) | 36 (72%) | 0.60 |
| Systolic BP mm Hg (baseline) | 124±17 | 124±16 | 128±19 | 0.59 |
| Ejection fraction,% | 59±8 | 55±11 | 63±9 | <0.0001 |
| AR ≥2, n (%) | 123 (35%) | 9 (18%) | 1 (2%) | <0.0001 |
| Aorta diameter at baseline | ||||
| Aortic annulus, mm | 25.0±3 | 24.6±3 | 24.6±2 | 0.49 |
| Sinuses of Valsalva, mm | 37.1±6 | 41.5±6 | 41.8±6 | <0.0001*† |
| Sinotubular junction, mm | 31.5±5 | 37.5±5 | 33.3±5 | <0.0001*†‡ |
| Ascending aorta, mm | 37.9±6 | 44.5±4 | 32.4±5 | <0.0001*†‡ |
| Dilatation rate, mm/year | ||||
| Aortic annulus | 0.05±0.2§ | 0.005±0.2 | 0.04±0.7 | 0.51 |
| Sinuses of Valsalva | 0.21±0.4§ | 0.09±0.2§ | 0.49±0.5§ | <0.0001*†‡ |
| Sino-tubular junction | 0.18±0.5§ | 0.10±0.2§ | 0.10±1.2 | 0.50 |
| Ascending aorta | 0.42±0.6§ | 0.20±0.3§ | 0.12±1.0§ | 0.0005*† |
| Maximal dilatation rate | 0.42±0.6 | 0.20±0.3 | 0.49±0.5 | 0.02*‡ |
*Indicates significant differences between BAV and DA.
†Indicates significant differences between BAV and MFS.
‡Indicates significant differences between MFS and DA.
§Indicates significant differences between baseline and follow-up diameters.
Larger baseline aortic diameters in DA patients reflect the inclusion criteria of 40 mm for these patients versus 37 mm for BAV and MFS.
AR, aortic regurgitation; BAV, bicuspid aortic valve; BP, blood pressure; DA, degenerative aortopathy; MFS, Marfan syndrome.