Unadjusted and adjusted HRs from the multivariable Cox proportional hazards model for MACE
| MACE | Bleeding type | Unadjusted | Adjusted | ||
|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | ||
| 30-day MACE | BARC 2 | 1.12 | 0.56 to 3.52 | 0.87 | 0.27 to 2.78 |
| BARC 3a | 1.26 | 0.56 to 2.86 | 1.04 | 0.45 to 2.38 | |
| BARC 3b | 5.01 | 2.55 to 9.84 | 3.81 | 1.89 to 7.72 | |
| Age per 1-year increase | 1.04 | 1.03 to 1.06 | 1.04 | 1.02 to 1.06 | |
| Previous MI | 1.46 | 0.99 to 2.16 | 1.20 | 0.74 to 1.94 | |
| Previous stroke | 1.93 | 1.13 to 3.29 | 1.31 | 0.76 to 2.28 | |
| Diabetes mellitus | 1.78 | 1.27 to 2.49 | 1.58 | 1.11 to 2.25 | |
| 30 days to 1 year MACE | BARC 2 | 2.44 | 1.08 to 5.53 | 1.66 | 0.72 to 3.84 |
| BARC 3a | 2.72 | 1.51 to 6.17 | 2.33 | 1.27 to 4.27 | |
| BARC 3b | 4.67 | 2.06 to 10.59 | 3.24 | 1.39 to 7.53 | |
| Age per 1-year increase | 1.05 | 1.03 to 1.06 | 1.04 | 1.02 to 1.06 | |
| Previous MI | 2.10 | 1.48 to 2.99 | 2.08 | 1.36 to 3.17 | |
| Previous stroke | 2.33 | 1.39 to 3.91 | 1.61 | 0.94 to 2.74 | |
| Diabetes mellitus | 1.30 | 0.91 to 1.84 | 1.07 | 0.74 to 1.54 | |
| 1-year MACE | BARC 2 | 1.79 | 0.92 to 3.47 | 1.27 | 0.65 to 2.50 |
| BARC 3a | 2.03 | 1.26 to 3.27 | 1.63 | 1.01 to 2.65 | |
| BARC 3b | 4.95 | 2.89 to 8.49 | 3.69 | 2.11 to 6.45 | |
| Age per 1-year increase | 1.04 | 1.03 to 1.06 | 1.04 | 1.03 to 1.05 | |
| Previous MI | 1.73 | 1.33 to 2.25 | 1.50 | 1.09 to 2.07 | |
| Previous stroke | 2.12 | 1.46 to 3.07 | 1.46 | 1.00 to 2.13 | |
| Diabetes mellitus | 1.56 | 1.22 to 1.98 | 1.04 | 1.03 to 1.05 | |
BARC, Bleeding Academic Research Consortium; MACE, major adverse cardiac events; MI, myocardial infarction.