NT proBNP (pg/mL) | Number with incident atrial fibrillation (rate per 1000 person years) | Unadjusted | Adjusted* | ||||
---|---|---|---|---|---|---|---|
HR | 95% CI | p Value | HR | 95% CI | p Value | ||
5–29.0 | 7 (1.0) | 1.0 | 1.0 | ||||
29.0–40.62 | 29 (3.7) | 4.2 | (1.8 to 9.6) | <0.001 | 3.2 | (1.4 to 7.3) | <0.01 |
40.62–70.4 | 35 (4.5) | 5.2 | (2.3 to 11.7) | <0.0001 | 3.6 | (1.6 to 8.1) | <0.005 |
70.4–133.3 | 64 (8.4) | 9.3 | (4.2 to 20.2) | <0.0001 | 5.6 | (2.5 to 12.5) | <0.0001 |
>133.4 | 144 (21.0) | 23.7 | (11.1 to 50.6) | <0.0001 | 11.4 | (5.1 to 25.3) | <0.0001 |
log (NT proBNP) per SD unit (1.2) | 2.6 | (2.4 to 3.0) | <0.0001 | 2.2 | (1.9 to 2.5) | <0.0001 |
*Adjusted for significant predictors selected by backward elimination: age, sex, race/ethnicity, height, BMI, cigarette smoking, hypertensive medications, systolic and diastolic blood pressure and diabetes.
BNP, brain natriuretic peptide.