Bassiouny et al15 | Bernard et al23 | Haines et al16 | Ichiki et al24 | Kaseno et al17 | Kim et al18 | Lakkireddy et al9 | Maddox et al19 | Mendoza et al25 | Nin et al20 | Pavaci et al26 | Rowley et al27 | Snipelisky et al.21 | Yamaji et al22 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients treated with dabigatran | 376 | 155 | 222 | 30 | 110 | 191 | 145 | 212 | 60 | 45 | 27 | 113 | 31 | 106 |
Dabigatran dosage | 150 mg twice daily | NA | 150 mg twice daily* | NA | 110 mg twice daily | 150 mg twice daily | 150 mg twice daily | 150 mg twice daily | 150 mg twice daily | 110 mg twice daily | NA | NA | 150 mg twice daily | 110 mg twice daily in 36 150 mg twice daily in 70 |
Timing of first held dose of dabigatrain | Morning of the day of the procedure or the night before | 24 h | ≤12 h in 35 12–24 h in 29 24–48 h in 102 >48 h in 18 Unknown in 18 | Morning of procedure | Morning of procedure | Night before procedure | Morning of procedure | Uninterrupted | Morning of procedure | Morning of the day before procedure | NA | Day before procedure | Morning of procedure | Morning of the day of the procedure |
Time interval for restarting after procedure | After arousal from anesthesia/sedation | Within 24 h | ≤6 h in 116 6–24 h in 83 >24 h in 1 Unknown in 2 | NA | Morning after procedure | 4 h | 3 h | Uninterrupted | Immediately after sheath removal (144.3 min) | 4 h after haemostasis at the puncture site | NA | > 24 h (day following) | Evening of procedure | Single dose, 3 h after the completion of the procedure |
Patients treated with warfarin | 623 | 44 | 222 | 180 | 101 | 572 | 145 | 251 | 58 | 45 | 27 | 169 | 125 | 397 |
Timing of first held dose of warfarin | Uninterrupted | Uninterrupted | ≤12 h in 74 12–24 h in 88 24–48 h in 15 >48 h in 25 | Uninterrupted | Uninterrupted | Uninterrupted | Uninterrupted | Uninterrupted | Uninterrupted | Morning of the day before procedure | Uninterrupted | Day before procedure | Evening prior to the procedure | Uninterrupted in 203 patients. Interrupted 48 h before in 194 |
Timing for restarting warfarin | Uninterrupted | Uninterrupted | Day of the procedure | Uninterrupted | Uninterrupted | Uninterrupted | Uninterrupted | Uninterrupted | Uninterrupted | 4 h after haemostasis at the puncture site | Uninterrupted | Day after procedure | Evening of procedure | Day after procedure in patients who stopped warfarin |
Target ACT (seconds) during procedure | 350–450 | NA | 300–350 at least | NA | 300–350 | 300–350 | 300–400 | >350–400 | 300–350 | 300–400 | 250–300 | NA | >350 | 300–350 |
Follow-up duration | 1 month | 1 month | Periprocedural/ hospital discharge | NA | At least 2 months | 3 months | 30 days | Periprocedural/ hospital discharge | 1 month | 2 weeks | NA | 30 days | 1 week | 3 months |
*Except for one elderly patient who took the 110 mg twice daily dose.
ACT, activated clotting time; NA, not available.