Univariable predictors of outcome
| HR | 95% CI | p Value | C Index | ||
|---|---|---|---|---|---|
| Demographics and clinical variables | |||||
| Gender, male | 1.49 | (0.72 to 3.05) | 0.28 | 0.596 | |
| Body mass index ≥30 (kg/m2) | 1.89 | (0.84 to 4.26) | 0.12 | 0.556 | |
| Age at repair ≥7 years | 2.51 | (1.25 to 5.05) | 0.01 | 0.596 | |
| Age at CMR ≥50 years | 3.96 | (1.77 to 8.83) | 0.001 | 0.579 | |
| TOF with pulmonary atresia | 3.34 | (1.63 to 6.83) | 0.001 | 0.636 | |
| Prior systemic-pulmonary artery shunt | 2.40 | (1.18 to 4.86) | 0.02 | 0.618 | |
| RV-to-PA conduit | 3.68 | (1.80 to 7.49) | <0.001 | 0.634 | |
| Atrial arrhythmia* | 4.52 | (2.24 to 9.13) | <0.001 | 0.643 | |
| Ventricular arrhythmia† | 2.23 | (1.08 to 4.57) | 0.03 | 0.566 | |
| ECG variables | |||||
| QRS duration (ms) | ↑10 | 1.11 | (0.97 to 1.27) | 0.12 | 0.578 |
| QRS duration ≥180 (ms) | 3.17 | (1.42 to 7.10) | 0.005 | 0.586 | |
| Exercise variables | |||||
| Percent predicted peak work rate | ↓5 | 1.28 | (1.05 to 1.56) | 0.02 | 0.735 |
| Percent predicted peak VO2 | ↓5 | 1.20 | (1.01 to 1.43) | 0.03 | 0.725 |
| Percent predicted VAT | ↓5 | 1.37 | (0.81 to 2.31) | 0.25 | 0.735 |
| CMR variables | |||||
| RV end-diastolic volume index (mL/m2) | ↑5 | 1.00 | (0.96 to 1.03) | 0.77 | 0.500 |
| RV end-systolic volume index, mL/m2) | ↑5 | 1.03 | (0.99 to 1.07) | 0.15 | 0.609 |
| RV EF (%) | ↓5 | 1.36 | (1.14 to 1.61) | <0.001 | 0.710 |
| RV mass index (g/m2) | ↑10 | 1.25 | (1.14 to 1.36) | <0.001 | 0.758 |
| RV mass z score | ↑1 | 1.12 | (1.07 to 1.17) | <0.001 | 0.769 |
| RV mass/volume (g/mL) | ↑0.1 | 1.50 | (1.29 to 1.75) | <0.001 | 0.774 |
| Pulmonary regurgitation (%) | ↑5 | 0.96 | (0.86 to 1.08) | 0.48 | 0.516 |
| LV end-diastolic volume index (mL/m2) | ↑5 | 1.06 | (0.98 to 1.13) | 0.13 | 0.522 |
| LV end-systolic volume index (mL/m2) | ↑5 | 1.15 | (1.07 to 1.24) | <0.001 | 0.650 |
| LV EF (%) | ↓5 | 1.40 | (1.15 to 1.70) | 0.001 | 0.697 |
| LV mass index (g/m2) | ↑10 | 1.28 | (1.19 to 1.39) | <0.001 | 0.749 |
| LV mass/volume (g/mL) | ↑0.1 | 1.16 | (1.07 to 1.27) | <0.001 | 0.765 |
| RV/LV end-diastolic volume ratio | ↓1 | 1.32 | (0.71 to 2.45) | 0.39 | 0.575 |
*Defined as atrial flutter, atrial fibrillation, or supraventricular tachycardia.
†Defined >20 couplets or >100 isolated premature ventricular complexes in a 24-h period, or nonsustained VT.
CMR, cardiac MR; PA, pulmonary artery; TOF, tetralogy of Fallot; VAT, ventilatory aerobic threshold; VT, ventricular tachycardia.