Study | N total | Follow-up (years) | N cases | Person-year follow-up | Event rates (per 1000 person-years) | Adjusted factors | Study quality |
---|---|---|---|---|---|---|---|
Masaki et al16 | 3522 | 4.0 | 473 | 14 088 | 33.6 | Age, SBP, DM, BMI, smoking, alcohol intake, physical activity, HCT, previous CAD, stroke and cancer, and antihypertensive medications | 8 |
Fisher et al20 | 179 | 4.7 | 97 | 835 | 116.2 | Age, sex, hypertension, DM, smoking, PP, previous CAD, stroke, cancer and COPD | 8 |
Sasaki et al17 | 304 | 4.0 | 136 | 1216 | 111.8 | Age, SBP, DM, serum albumin, and previous CAD, PAD and stroke | 7 |
Rose et al3 | 13 152 | 13.0 | 1693 | 17 0976 | 9.9 | Age, sex, race, educational level, SBP, DM, BMI, resting HR, alcohol intake, physical activity, HDL-C, LDL-C and antihypertensive medications | 9 |
Weiss et al21 | 471 | 3.5 | 249 | 1649 | 151.0 | Age, sex, hypertension, DM, BMI, smoking, previous IHD, CHF, Parkinsonism and medications used | 9 |
Verwoert et al18 | 5064 | 7.8 | 1835 | 39 499 | 16.5 | Age, sex, SBP, DBP, DM, BMI, TC, HDL-C, smoking and use of hypertensive medications | 9 |
Fedorowski et al11 | 32 797 | 22.7 | 6904 | 744 492 | 9.3 | Age, sex, hypertension, DM, TC, BMI, smoking and pervious cancer | 9 |
Badia et al19 | 323 | 4.0 | 135 | 1292 | 104.5 | Age, sex, hypertension, DM, SBP, DBP, smoking, alcohol intake and medications used | 8 |
Lagro et al22 | 313 | 2.0 | 58 | 626 | 92.7 | Age, sex, SBP, DBP, hypertension, DM, BMI, previous CVD, cancer and medications used | 7 |
Quality of the included studies was evaluated using the Newcastle-Ottawa Scale (range, 1–9 stars).
BMI, body mass index; CAD, coronary artery disease; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; DBP, diastolic blood pressure; DM, diabetes mellitus; HCT, haematocrit; HDL-C, high-density lipoprotein cholesterol; HR, heart rate; IHD, ischaemic heart disease; LDL-C, low-density lipoprotein cholesterol; PAD, peripheral artery disease; PP, pulse pressure; SBP, systolic blood pressure; TC, total cholesterol.