Table 1

Characteristics of studies included in the meta-analysis

StudyYearMean follow-up (years)Medications usedN (treatment/control)AgeControl
Difference in SBP/DBP from baseline (mm Hg)
Difference in SBP/DBP from baseline (mm Hg)
Coope J19864.4Atenolol and bendrofluazide419/46568.8−14/−10−32/−22
EWHPE19854.6Hydrochlorothiazide plus triamterene416/42472−15/−11−35/−16
HYVET20082.08Indapamide 1.5 mg ±perindopril1933/191283.6−14.5/−6.8−29.5/−12.9
MRC (b-blocker)19925.8Atenolol 50 mg1101/221270.3−19.5/−6−32.5/−15
MRC (diuretic)19925.8Hydrochlorothiazide 25–50 mg plus amiloride 2.5–5 mg daily1081/221370.3−19.5/−6−34/−14.5
SHEP19914.5Chlorthalidone 12.5–25 mg and atenolol 25–50 mg2365/237971.6−15/−9−27/−9
STOP-Hypertension19912.1Atenolol 50 mg or hydrochlorothiazide 25 mg plus amiloride 2–5 mg or metoprolol 100 mg or pindolol 5 mg815/81275.7−2/−7−29/−17
Syst-Eur19972Enalapril 5–20 mg daily and hydrochlorothiazide 12.5–25 mg2398/229770.3−13/−2−23/−7
Syst-China20002Enalapril 5–20 mg daily and hydrochlorothiazide 12.5–25 mg daily1253/114166.5−11/−2−20/−5
ACCOMPLISH20083Benazepril plus amlodipine or benazepril plus hydrochlorothiazide5744/576268.4−12.9/−5.6−13.7/−6.8
ALLHAT (A vs C)20024.9Amlodipine 2.5–10 mg or chlorthalidone 12.5–25 mg8784/520466.9−11.5/−9.3−12.3/−8.6
ALLHAT (L vs c)20024.9Lisinopril 10–40 mg or chlorthalidone 12.5–25 mg8784/518566.9−10.5/−8.7−12.3/−8.6
ANBP-220034.1ACE inhibitors or thiazide diuretics (enalapril or hydroclorthiazide recommended)3044/303971.9−26/−12−26/−12
JATOS20082Strict or mild treatment (background medication was efonidipine)2212/220673.6−25.9/−11−35.7/−14.3
INVEST20032Verapamil versus atenolol11 267/11 30966.1−18.7/−10−19/−10.2
LIFE20024.7Losartan or atenolol586/60967.4−29/−16.8−30.3/−16.6
STOP-219994Atenolol 50 mg, metoprolol 100 mg, pindolol 5 mg or hydrochlorothiazide 25 mg plus amiloride 2.5 mg daily or enalapril 10 mg or lisinopril 10 mg, or felodipine 2.5 mg or isradipine 2–5 mg daily4401/221376.0−36/−17−35/−17
VALISH20103.07Strict versus moderate control1545/153476.1−27.6/−4.7−32.9/−6.9
VALUE20044.2Valsartan or amlodipine7596/764967.3−15.2/−8.2−17.3/−9.9
  • ACCOMPLISH, Avoiding Cardiovascular Events in Combination Therapy in Patients Living with Systolic Hypertension; DBP, diastolic blood pressure; HYVET, Hypertension in the Very Elderly; JATOS, Japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients; MRC, Medical Research Council; SBP, systolic blood pressure.