Comparisons of LGE-CMR, histological and echocardiographic findings in 13 obstructive HCM patients with and 8 patients without septal LGE
| With septal LGE (n=13) | Without septal LGE (n=8) | p Values | |
|---|---|---|---|
| Echocardiography | |||
| Maximal wall thickness (mm) | 21±3 | 18±1 | 0.06 |
| Wigle's score | 6.4±2.6 | 4.7±2.0 | 0.20 |
| Spirito–Maron index | 68±11 | 60±7 | 0.13 |
| Peak LVOTG (mm Hg) | 69±26 | 69±15 | 1.00 |
| Ejection fraction (%) | 66±6 | 67±6 | 0.69 |
| Global longitudinal strain (%) | −13.6±2.6 | −15.6±3.1 | 0.14 |
| Septal longitudinal strain (%) | −15.3±3.6 | −14.7±2.5 | 0.74 |
| Global circumferential strain (%) | −27.4±6.6 | −31.0±6.6 | 0.32 |
| Septal circumferential strain (%) | −28.9±6.4 | −35.8±3.8 | 0.04 |
| Histology | |||
| Histological fibrosis present (yes) | 13 (100%) | 7 (88%) | 0.38 |
| %Area of total amount of fibrosis | 20 (9, 58) | 14 (5, 19) | 0.41 |
| %Area of replacement fibrosis | 4 (1, 9) | 3 (1, 4) | 0.60 |
| %Area of interstitial fibrosis | 17 (7, 55) | 9 (2, 16) | 0.24 |
Values are n(%), median(25%, 75% percentiles) and mean±SD, when appropriate.
BSA, body surface area; HCM, hypertrophic cardiomyopathy; LGE, late gadolinium enhancement; LGE-CMR, LGE cardiac magnetic resonance; LVOTG, LV outflow tract gradient.