Markers of inflammation and measures of vascular function
| Characteristic | Women | Men | p Value |
|---|---|---|---|
| Markers of inflammation | Median (range), (n) | Median (range), (n) | |
| IL-6, pg/mL | 1.2 (0.13–9.24), (n=1721) | 1.1 (0.16–9.73), (n=1683) | <0.001 |
| CRP, mg/mL | 2.4 (0.15–67.0), (n=1750) | 1.3 (0.15–97.4), (n=1731) | <0.001 |
| TNF-α R1, pg/mL | 1238 (603–3864), (n=959) | 1289 (653–4918), (n=853) | <0.001 |
| Measures of vascular function | Median (range), (n=1762) | Median (range), (n=1739) | |
| Baseline brachial diameter, mm | 3.8 (2.2–6.0) | 4.8 (2.5–7.1) | <0.001 |
| Flow-mediated dilation, mm | 0.16 (0–0.74) | 0.17 (-0.07–0.63) | 0.031 |
| Flow-mediated dilation, % | 4.2 (0–24.8) | 3.5 (0–14.8) | <0.001 |
CRP, C reactive protein; IL-6, interleukin-6; TNF-α R1, tumour necrosis factor-α receptor 1.