Relationship between flow-mediated dilation and inflammatory markers by race/ethnic group
| Parameter and model | Spearman partial correlation coefficient | ||
|---|---|---|---|
| IL-6 | CRP | TNF-α R1 | |
| Flow-mediated dilation % | |||
| Caucasian | (n=1149) | (n=1168) | (n=423) |
| Detectable correlation* | 0.082 | 0.082 | 0.136 |
| Univariate | −0.091(0.002) | 0.055(0.06) | −0.046(0.34) |
| Multivariate† | −0.016(0.60) | 0.046(0.11) | 0.089(0.07) |
| Multivariate‡ | −0.017(0.57) | 0.048(0.11) | 0.045(0.37) |
| Chinese | (n=624) | (n=632) | (n=581) |
| Detectable correlation* | 0.112 | 0.111 | 0.116 |
| Univariate | −0.102(0.01) | −0.019(0.636) | −0.123(0.003) |
| Multivariate† | −0.053(0.19) | −0.014(0.727) | 0.011(0.80) |
| Multivariate‡ | −0.044(0.28) | 0.009(0.82) | 0.044(0.30) |
| African American | (n=754) | (n=782) | (n=349) |
| Detectable correlation* | 0.102 | 0.100 | 0.149 |
| Univariate | −0.068(0.07) | 0.018(0.62) | −0.159(0.003) |
| Multivariate† | −0.044(0.23) | −0.004(0.905) | −0.088(0.10) |
| Multivariate‡ | −0.039(0.31) | −0.009(0.81) | −0.117(0.040) |
| Hispanic | (n=877) | (n=899) | (n=459) |
| Detectable correlation* | 0.094 | 0.093 | 0.130 |
| Univariate | −0.122(0.0003) | 0.003 (0.92) | −0.086 (0.07) |
| Multivariate† | −0.064 (0.06) | −0.031 (0.35) | 0.036 (0.44) |
| Multivariate‡ | −0.062 (0.07) | −0.012 (0.72) | 0.029 (0.55) |
*Detectable correlation: the minimum of detectable absolute value of the correlation with the corresponding sample size with 80% power at a significance level of 0.05.
†Multivariate analysis adjusted for age and gender.
‡Multivariate analysis included age, gender, education, income, low-density lipoprotein, glucose, diabetes, hypertension status and treatment, waist circumference, triglycerides, baseline brachial diameter and use of medications that may alter inflammation.
CRP, C reactive protein; IL-6, interleukin-6; TNF-α R1, tumour necrosis factor-α receptor 1.