Morphological and histological parameters
| Sham | PMI | BNP-PMI | BB-PMI | BB-BNP-PMI | |
|---|---|---|---|---|---|
| Heart weight index (mg/g) | 4.9±0.2 | 5.9±0.3‡ | 6.2±0.1‡ | 5.5±0.1†,§ | 5.3±1.1*,||,¶ |
| Pleural effusion (%) | 0 | 58† | 57† | 69‡,§ | 33*,§,# |
| Lung congestion (%) | 0 | 41† | 42† | 69‡,§ | 33*,§,# |
| LV end-diastolic dimension (mm) | 25.4±0.5 | 52.4±0.4‡ | 47.1±0.3‡ | 42.1±0.5†,§ | 39.9±0.4†,§ |
| LV shortening fraction (%) | 58.9±1.3 | 17.4±1.1‡ | 17.5±0.8‡ | 24.6±0.6†,§ | 29.6±0.9†,||,¶ |
| Collagen (%) | 0.1±0.0 | 5.2±1.8‡ | 3.6±0.2‡,§ | 4.6±1.9‡ | 2.4±1.5†,||,¶ |
| Cell volume (10−5 mm3) | 3.5±0.1 | 5.5±0.5‡ | 4.8±0.4† | 4.3±0.3*,§ | 3.7±0.4||,¶ |
Heart weight index. Percentage of animals exhibiting pleural effusion and lung congestion (15 mice/group). LV end-diastolic dimensions and shortening fraction (14 mice/group). Collagen content (percentage of the total area of myocardial tissue, 8 mice/group) and cell volume (n=30 cells, 3 mice/group). *,†,‡ p<0.05, p<0.01, p<0.001 versus Sham; §,|| p<0.05, p<0.01 versus PMI; ¶,# p<0.05, p<0.01 versus BB-PMI.
BB, β1-adrenergic blocker; BNP, B-type natriuretic peptide; PMI, postmyocardial infarction.