Table 1

Morphological and histological parameters

Heart weight index (mg/g)4.9±0.25.9±0.3‡6.2±0.1‡5.5±0.1†,§5.3±1.1*,||,¶
Pleural effusion (%)058†57†69‡,§33*,§,#
Lung congestion (%)041†42†69‡,§33*,§,#
LV end-diastolic dimension (mm)25.4±0.552.4±0.4‡47.1±0.3‡42.1±0.5†,§39.9±0.4†,§
LV shortening fraction (%)58.9±1.317.4±1.1‡17.5±0.8‡24.6±0.6†,§29.6±0.9†,||,¶
Collagen (%)0.1±0.05.2±1.8‡3.6±0.2‡,§4.6±1.9‡2.4±1.5†,||,¶
Cell volume (10−5 mm3)3.5±0.15.5±0.5‡4.8±0.4†4.3±0.3*,§3.7±0.4||,¶
  • Heart weight index. Percentage of animals exhibiting pleural effusion and lung congestion (15 mice/group). LV end-diastolic dimensions and shortening fraction (14 mice/group). Collagen content (percentage of the total area of myocardial tissue, 8 mice/group) and cell volume (n=30 cells, 3 mice/group). *,†,‡ p<0.05, p<0.01, p<0.001 versus Sham; §,|| p<0.05, p<0.01 versus PMI; ¶,# p<0.05, p<0.01 versus BB-PMI.

  • BB, β1-adrenergic blocker; BNP, B-type natriuretic peptide; PMI, postmyocardial infarction.