1st tertile vs AVC=0 | 2nd tertile vs AVC=0 | 3rd tertile vs AVC=0 | ||||
---|---|---|---|---|---|---|
Model | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value |
(a) Coronary events | ||||||
Unadjusted | 1.76 (0.82 to 3.79) | 0.15 | 2.74 (1.47 to 5.10) | 0.002 | 4.13 (2.44 to 6.99) | <0.001 |
Age and sex adjusted | 1.07 (0.49 to 2.32) | 0.87 | 1.72 (0.91 to 3.24) | 0.09 | 2.49 (1.44 to 4.29) | 0.001 |
+Traditional CV risk factors* | 0.98 (0.45 to 2.15) | 0.97 | 1.54 (0.81 to 2.90) | 0.19 | 2.21 (1.28 to 3.81) | 0.005 |
+CAC score, log (CAC+1) | 0.88 (0.41 to 1.91) | 0.75 | 1.14 (0.61 to 2.16) | 0.68 | 1.55 (0.89 to 2.69) | 0.12 |
(b) Stroke | ||||||
Unadjusted | 1.93 (0.84 to 4.41) | 0.12 | 1.25 (0.46 to 3.42) | 0.66 | 2.64 (1.28 to 5.46) | 0.009 |
Age and sex adjusted | 1.11 (0.48 to 2.57) | 0.81 | 0.75 (0.27 to 2.06) | 0.57 | 1.52 (0.73 to 3.20) | 0.27 |
+Traditional CV risk factors* | 1.05 (0.45 to 2.45) | 0.90 | 0.67 (0.24 to 1.85) | 0.44 | 1.43 (0.68 to 3.02) | 0.34 |
+CAC score, log (CAC+1) | 1.02 (044 to 2.36) | 0.97 | 0.60 (0.22 to 1.65) | 0.32 | 1.24 (0.59 to 2.62) | 0.57 |
(c) CVD events | ||||||
Unadjusted | 1.84 (1.07 to 3.16) | 0.03 | 2.20 (1.34 to 3.61) | 0.002 | 3.29 (2.15 to 5.02) | <0.001 |
Age and sex adjusted | 1.03 (0.60 to 1.79) | 0.91 | 1.29 (0.78 to 2.13) | 0.32 | 1.86 (1.20 to 2.86) | 0.005 |
+Traditional CV risk factors* | 0.97 (0.56 to 1.68) | 0.90 | 1.16 (0.70 to 1.92) | 0.57 | 1.67 (1.08 to 2.58) | 0.02 |
+CAC score, log (CAC+1) | 0.89 (0.51 to 1.54) | 0.67 | 0.94 (0.57 to 1.55) | 0.80 | 1.29 (0.83 to 2.00) | 0.26 |
*Traditional cardiovascular risk factors included systolic blood pressure, low density lipoprotein cholesterol, high density lipoprotein cholesterol, diabetes, and smoking.
AVC, aortic valve calcium; CAC, coronary artery calcium; CV, cardiovascular; CVD, cardiovascular disease.