NRI and IDI for the combined assessment of traditional risk markers, AVC, and CAC in predicting coronary events, stroke, and CVD events
| Model | IDI (95% CI) | p Value | NRI (95% CI) | p Value |
|---|---|---|---|---|
| Coronary event: FRV vs FRV+AVC (Tert.) | 0.004 (0.000 to 0.009) | 0.075 | 0.035 (−0.025 to 0.095) | 0.26 |
| Stroke: FRV vs FRV+AVC (Tert.) | 0.001 (0.000 to 0.003) | 0.13 | 0.018 (−0.009 to 0.045) | 0.20 |
| CVD event: FRV vs FRV+AVC (Tert.) | 0.002 (−0.001 to 0.005) | 0.26 | 0.016 (−0.015 to 0.048) | 0.30 |
| Coronary event: FRV vs FRV+CAC+AVC (Tert.) | 0.003 (−0.001 to 0.007) | 0.15 | 0.005 (−0.051 to 0.060) | 0.87 |
| Stroke: FRV vs FRV+CAC+AVC (Tert.) | 0.002 (0.000 to 0.004) | 0.051 | −0.001 (−0.031 to 0.008) | 0.25 |
| CVD event: FRV vs FRV+CAC+AVC (Tert.) | 0.002 (−0.001 to 0.004) | 0.15 | 0.019 (−0.003 to 0.041) | 0.093 |
NRI was calculated using event rate categories <10%, 10–20%, >20%.
AVC, aortic valve calcification; CAC, coronary artery calcification; CVD, cardiovascular disease; FRV, Framingham risk variables (including age, sex, diabetes, systolic blood pressure, LDL and HDL cholesterol, and present smoking status); HDL, high density lipoprotein; IDI, integrated discrimination improvement; LDL, low density lipoprotein; NRI, net reclassification index; Tert., tertile.