Table 4

Univariate and multivariate Cox regression survival analysis for the secondary endpoint (all-cause mortality and heart failure related events)

VariablesUnivariate analysisMultivariate analysis
HR95% CIp ValueHR95% CIp Value
Age, per year1.0391.018 to 1.061<0.0011.0261.003 to 1.0500.030
Male sex0.9080.557 to 1.4810.699
Ischaemic aetiology1.6321.035 to 2.5750.0351.0400.602 to 1.7970.887
Atrial fibrillation1.0580.683 to 1.6390.801
Diabetes1.2770.777 to 2.0980.335
ICD device and lead1.2830.764 to 2.1550.347
Percentage of pacing, per %1.0030.999 to 1.0080.1571.0010.996 to 1.0070.636
LVEDV, per mL1.0061.003 to 1.008<0.001
LVESV, per mL1.0081.005 to 1.011<0.001
LVEF, per %0.9580.939 to 0.977<0.0010.9710.949 to 0.9940.013
Mitral regurgitation grade 0 (reference group)0.0110.014
Mitral regurgitation grade 1 (vs reference group)0.5110.277 to 0.9431.1750.618 to 2.235
Mitral regurgitation grade 2 (vs reference group)1.0420.572 to 1.8961.3450.687 to 2.633
Mitral regurgitation grade 3 (vs reference group)2.3711.081 to 5.2012.6591.126 to 6.276
Mitral regurgitation grade 4 (vs reference group)0.9150.124 to 6.7326.5591.861 to 23.116
RV end-diastolic area, per mm21.0481.011 to 1.0860.010
RV fractional area change, per %0.9660.949 to 0.984<0.001
TAPSE, per mm0.9130.864 to 0.9630.0010.9710.917 to 1.0280.307
Right atrial diameter, per mm1.3551.082 to 1.6990.008
Tricuspid annular diameter, per mm1.5091.204 to 1.892<0.001
sPAP, per mm Hg1.0591.042 to 1.075<0.001
Significant lead-induced TR1.6411.087 to 2.4800.0191.6491.043 to 2.5990.032
  • Bold values are statistically significant.

  • ICD, implantable cardioverter-defibrillator; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular EF; LVESV, left ventricular end-systolic volume; sPAP, systolic pulmonary arterial pressure; TAPSE, tricuspid annular plane systolic excursion; TR, tricuspid regurgitation.