Table 3

Correlation between echocardiographic parameters of the severity of aortic valve stenosis and measures of body size in a total of 4368 patients with aortic valve stenosis

	Retrospective cohort (n=2843)					Prospective cohort (n=1525)
	Height	Weight	BSA	BMI	AVA	Height	Weight	BSA	BMI	AVA
Jet velocity	−0.076	−0.066	−0.074	−0.030		0.052	0.007	0.027	−0.031
Mean pressure gradient	−0.077	−0.064	−0.073	−0.026		0.049	0.004	0.024	−0.033
AVA	0.319	0.281	0.317	0.126		0.250	0.247	0.279	0.115
Linear adjustment
AVA/height	0.181	0.211	0.218	0.133	0.989	0.107	0.175	0.169	0.132	0.988
AVA/weight	0.020	−0.243	−0.205	−0.305	0.845	−0.019	−0.241	−0.184	−0.271	0.863
AVA/BSA	0.104	−0.022	0.007	−0.094	0.946	0.031	−0.016	−0.002	−0.040	0.955
(AVA_index)
AVA/BMI	0.300	−0.076	0.006	−0.284	0.903	0.263	−0.080	0.046	−0.278	0.910
Allometric adjustment
AVA/height^2.04	0.023	0.128	0.110	0.138	0.950	−0.052	0.093	0.047	0.149	0.949
AVA/a*height^b	0.002	0.117	0.089	0.138	0.943	0.005	0.122	0.091	0.143	0.966
AVA/a*weight^b	0.170	0.004	0.065	−0.106	0.956	0.122	0.004	0.052	−0.080	0.966
AVA/a*BSA^b	0.067	−0.031	0.001	−0.082	0.939	0.038	−0.009	0.006	−0.035	0.984
AVA/a*BMI^b	0.321	0.177	0.252	0.001	0.991	0.260	0.155	0.216	0.000	0.970

Bivariate Pearson coefficients are shown for direct correlations (top), after linear adjustment (middle) and after allometric adjustment for body size (bottom). Residual correlation of the adjusted parameters with AVA is presented in column 4 (retrospective cohort) and column 8 (prospective cohort). Non-linear regression is based on de Simone`s work for height^2.04 or the formula AVA=a×xb.4 ,17 Individual values for the scaling factor a and the scaling exponent b are given in the online supplementary appendix table. For details see text.
AVA_index is used for AVA indexed to BSA (AVA/BSA) as in current guidelines.1 ,2
AVA, aortic valve area; BSA, body surface area, BMI, body mass index.