Univariate and multivariate Cox regression analysis of variables associated with the combined end-point death—myocardial infarction
| Univariate Cox regression | Multivariate Cox regression* | |||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Increasing age (per decade) | 1.36 (1.28 to 1.45) | <0.001 | 1.28 (1.18 to 1.39) | <0.001 |
| Female gender | 1.24 (1.07 to 1.44) | 0.004 | 1.08 (0.90 to 1.30) | 0.402 |
| Comorbidities | ||||
| History of diabetes mellitus | 1.55 (1.34 to 1.80) | <0.001 | 1.45 (1.22 to 1.71) | <0.001 |
| History of hypertension | 1.20 (1.03 to 1.40) | 0.021 | 1.00 (0.82 to 1.21) | 0.994 |
| History of peripheral vascular disease* | 1.85 (1.46 to 2.35) | <0.001 | – | |
| History of cerebrovascular disease* | 1.70 (1.26 to 2.29) | 0.001 | – | |
| Increased creatinine (> 200 mol/L) | 4.01 (2.75 to 5.85) | <0.001 | 2.56 (1.64 to 3.99) | <0.001 |
| LV systolic dysfunction | 1.57 (1.38 to 1.78) | <0.001 | 1.36 (1.18 to 1.56) | <0.001 |
| History of previous myocardial infarction | 1.21 (1.04 to 1.40) | 0.011 | 1.15 (0.97 to 1.36) | 0.113 |
| Angiographic variables | ||||
| Syntax score (per unit) | 1.03 (1.02 to 1.04) | <0.001 | 1.02 (1.01 to 1.03) | <0.001 |
| Severe lesion calcification | 1.86 (1.60 to 2.16) | <0.001 | 1.23 (1.02 to 1.49) | 0.031 |
*Because of missing data, the history of cerebrovascular and peripheral vascular disease was not entered into the multivariate analysis.