Table 2

Multivariate model detailing the components of the MACS rule (rounded values are presented)

VariableConstantOR (95% CI)p Value
a. High sensitivity troponin T*0.0681.1 (1.0 to 1.1)<0.0001
b. Heart-type fatty acid binding protein*0.171.2 (1.0 to 1.4)0.018
c. ECG ischaemia1.755.8 (3.1 to 10.8)<0.0001
d. Sweating observed1.856.3 (3.0 to 13.3)<0.0001
e. Vomiting1.725.6 (1.9 to 16.6)0.002
f. Systolic blood pressure <100 mm Hg1.464.3 (1.2 to 15.1)0.022
g. Worsening angina0.922.5 (1.2 to 5.2)0.014
h. Pain radiating to right arm or shoulder0.872.4 (1.0 to 5.6)0.044
  • The model estimates the probability (p) of MACE as follows (rounded values are presented): p=1/(1+e−(0.068a+0.17b+1.75c+1.85d+1.72e+1.46f+0.92g+0.87h− 4.83)). For each categorical variable, a value of 1 is assigned if the characteristic is present and 0 if absent.

  • *ORs are presented for a 1 unit increase (ng/L for hs-cTnT; ng/mL for H-FABP).

  • MACE, major adverse cardiac events; MACS, Manchester Acute Coronary Syndromes.