Table 3

Metrics for improvement in risk prediction of cardiovascular disease with addition of sST2

c-IndexIDIContinuous NRICategorical NRI
OldNewDifferencep valuevaluep valuevaluep valuevaluep value
  • The c-index p value compares the addition of sST2 to a base model including Framingham risk factors (HDL and non-HDL cholesterol, systolic blood pressure (BP), smoking, prevalent diabetes) and area. IDI Integrated Discrimination Improvement, NRI Net Reclassification Improvement (categorical; 0–5%, 5–10%, 10–20%, >20%), NRI continuous, clinical NRI (5–20%). ‘–’ indicates that the base model was more predictive than the new model with sST2.