Linear associations between GRS and risk factors with age of first acute coronary syndrome
| Unadjusted | Adjusted* | |||||
|---|---|---|---|---|---|---|
| β (years) | 95% CI | p Value | β (years) | 95% CIl | p Value | |
| GRS | −0.4 | −0.7 to −0.1 | 0.021 | −0.3 | −0.6 to −0.01 | 0.040 |
| Male sex | −8.2 | −10.5 to −5.8 | <0.001 | −6.9 | −9.7 to −4.1 | <0.001 |
| Hypertension | 6.0 | 3.8 to 8.2 | <0.001 | 3.4 | 1.2 to 5.6 | 0.003 |
| Diabetes | 3.1 | −0.2 to 6.4 | 0.062 | 0.3 | −2.7 to 3.3 | 0.846 |
| Hypercholesterolaemia | −0.4 | −2.6 to 1.9 | 0.745 | −1.1 | −3.1 to 1.0 | 0.302 |
| Current smoker | −8.5 | −10.6 to −6.5 | <0.001 | −8.1 | −10.0 to −6.1 | <0.001 |
| Body Mass Index | ||||||
| BMI 25–30 | −2.1 | −4.5 to 0.3 | 0.090 | −2.6 | −4.8 to −0.3 | 0.024 |
| BMI >30 | −4.5 | −7.49 to −1.59 | 0.003 | −5.2 | −7.9 to −2.6 | <0.001 |
| ASA use | 5.7 | 2.0 to 9.4 | 0.003 | 3.7 | 0.3 to 7.0 | 0.032 |
| HRT use† | −4.3 | −8.6 to 0.02 | 0.051 | −4.8 | −8.4 to −0.3 | 0.037 |
*Adjusted for age, sex, hypertension, diabetes, hypercholesterolaemia, current smoking, Body Mass Index, ASA use, HRT use and GRS.
†Limited to women only.
ASA, acetylsalicylic acid; BMI, Body Mass Index; GRS, Genetic Risk Score; HRT, hormone replacement therapy.