Baseline characteristics |
Age (years) mean (SD) | 48.79 (22.08) | 49.95 (23.03) | 47.55 (21.24) |
Male gender n (%) | 4225 (50.8) | 4225 (100) | 0 (0) |
Cardiovascular risk factors |
Current smokers n (%) | 2139 (25.72) | 1302 (30.8) | 837 (20.5) |
Former smokers n (%) | 1821 (21.9) | 1248.2 (29.52) | 573 (14.02) |
Hypertensive_AHA n (%) | 3810 (45.8) | 2261 (53.5) | 1549 (37.9) |
History of diabetes mellitus n (%) | 488 (5.9) | 274 (6.5) | 214 (5.2) |
Systolic blood pressure (mmHg) mean (SD) | 134 (27) | 137 (26) | 130 (27) |
Body Mass Index (kg/m²) mean (SD) | 26.15 (5.62) | 26.62 (4.88) | 25.48 (6.38) |
Total cholesterol (mmol/L) median IQR | 5.47 (1.39) | 5.5 (1.36) | 5.43 (1.43) |
HDL (mmol/L) median IQR | 1.34 (0.48) | 1.22 (0.4) | 1.51 (0.47) |
Endpoints during 15 years of follow-up |
Cardiovascular disease n (%) | 914 (11) | 650 (15.4) | 264 (6.5) |
Myocardial infarction n (%) | 359 (4.3) | 266 (6.3) | 93 (2.3) |
Coronary heart disease n (%) | 665 (8) | 499 (11.8) | 166 (4.1) |
Stroke (%) | 401 (4.8) | 273 (6.5) | 128 (3.1) |
Heart failure n (%) | 641 (7.7) | 383 (9.1) | 258 (6.3) |
MACE n (%) | 1183 (14.2) | 781 (18.5) | 402 (9.8) |
Death n (%) | 1136 (13.7) | 792 (18.7) | 344 (8.4) |
Biomarkers |
ST2 (ng/ml) median (IQR) | 26.95 (13.7) | 30.4 (14.87) | 23.9 (11.09) |
NTproBNP (pg/mL) median (IQR) | 44.32 (64.38) | 31.63 (57.37) | 55.79 (64.17) |
eGFR | 91.93 (32.5) | 80.69 (21.48) | 108.17 (25.23) |
hsTroponin (pg/mL), median (IQR) | 3.1 (2.9) | 3.6 (3.27) | 2.6 (2.4) |