Comparison of incidence and HR of ACS stratified by comorbidities between patients with and without scrub typhus
| Scrub typhus | ||||||||
|---|---|---|---|---|---|---|---|---|
| No | Yes | |||||||
| Variables | Event | PY | Rate† | Event | PY | Rate† | IRR (95% CI) | Adjusted HR‡ (95% CI) |
| Hypertension | ||||||||
| No | 155 | 103 923 | 1.49 | 50 | 24 041 | 2.08 | 1.39 (1.27 to 1.53)*** | 1 (Reference) |
| Yes | 54 | 4738 | 11.4 | 33 | 2700 | 12.2 | 1.07 (0.83 to 1.38) | 1.75 (1.27 to 2.42)*** |
| Diabetes | ||||||||
| No | 169 | 105 865 | 1.60 | 55 | 24 616 | 2.23 | 1.40 (1.27 to 1.54)*** | 1 (Reference) |
| Yes | 40 | 2796 | 14.3 | 28 | 2124 | 13.2 | 0.92 (0.69 to 1.24) | 2.72 (2.00 to 3.70)*** |
| Hyperlipidaemia | ||||||||
| No | 194 | 107 445 | 1.81 | 71 | 25 652 | 2.77 | 1.53 (1.40 to 1.68)*** | 1 (Reference) |
| Yes | 15 | 1216 | 12.3 | 12 | 1089 | 11.0 | 0.89 (0.56 to 1.42) | 1.52 (0.98 to 2.37) |
| CVA | ||||||||
| No | 184 | 106 840 | 1.72 | 74 | 26 121 | 2.83 | 1.65 (1.51 to 1.80)*** | 1 (Reference) |
| Yes | 25 | 1821 | 13.7 | 9 | 620 | 14.5 | 1.06 (0.65 to 1.72) | 1.36 (0.91 to 2.04) |
| COPD | ||||||||
| No | 195 | 107 509 | 1.81 | 71 | 25 938 | 2.74 | 1.51 (1.38 to 1.65)*** | 1 (Reference) |
| Yes | 14 | 1151 | 12.2 | 12 | 803 | 14.9 | 1.23 (0.75 to 2.00) | 1.59 (1.03 to 2.46)* |
| CHF | ||||||||
| No | 202 | 108 178 | 1.87 | 78 | 26 452 | 2.95 | 1.58 (1.45 to 1.72)*** | 1 (Reference) |
| Yes | 7 | 483 | 14.5 | 5 | 288 | 17.3 | 1.20 (0.59 to 2.43) | 1.61 (0.87 to 2.98) |
| Asthma | ||||||||
| No | 205 | 107 961 | 1.90 | 80 | 26 282 | 3.04 | 1.60 (1.47 to 1.75)*** | 1 (Reference) |
| Yes | 4 | 699 | 5.72 | 3 | 459 | 6.54 | 1.14 (0.54 to 2.42) | 0.73 (0.34 to 1.60) |
| CAD | ||||||||
| No | 183 | 106 761 | 1.71 | 70 | 25 985 | 2.69 | 1.57 (1.44 to 1.72)*** | 1 (Reference) |
| Yes | 26 | 1900 | 13.7 | 13 | 756 | 17.2 | 1.26 (0.82 to 1.92) | 1.53 (1.03 to 2.27)* |
*p< 0.05, ***p<0.001.
†Rate: incidence rate, per 1000 person-years.
‡Adjusted HR: multivariable analysis including age, sex and comorbidities of hypertension, diabetes, hyperlipidaemia, CVA, COPD, CHF, asthma and CAD.
ACS, acute coronary syndrome; CAD, coronary artery disease; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; IRR: incidence rate ratio; PY, person-years.