The risk of ACS in patients with scrub typhus associated with COPD, hypertension and diabetes
| ACS | Adjusted HR† | ||||||
|---|---|---|---|---|---|---|---|
| N | n | PY | Rate‡ | (95% CI) | |||
| Scrub typhus | COPD | Hypertension | |||||
| − | − | − | 19 469 | 153 | 103 273 | 1.48 | 1 (Reference) |
| + | − | − | 4413 | 45 | 23 460 | 1.92 | 1.42 (1.02 to 1.98)* |
| − | + | − | 157 | 2 | 649 | 3.08 | 0.68 (0.17 to 2.76) |
| − | − | + | 1096 | 42 | 4236 | 9.91 | 2.59 (1.81 to 3.70)*** |
| + | + | − | 116 | 5 | 581 | 8.60 | 2.73 (1.12 to 6.68)* |
| − | + | + | 138 | 12 | 502 | 23.9 | 4.66 (2.55 to 8.53)*** |
| + | − | + | 619 | 26 | 2478 | 10.5 | 3.38 (2.21 to 5.16)*** |
| + | + | + | 67 | 7 | 222 | 31.6 | 6.82 (3.17 to 14.7)*** |
| Scrub typhus | COPD | Diabetes | |||||
| − | − | − | 19 930 | 161 | 104 975 | 1.53 | 1 (Reference) |
| + | − | − | 4563 | 47 | 23 930 | 1.96 | 1.37 (0.99 to 1.89) |
| − | + | − | 222 | 8 | 889 | 8.99 | 1.78 (0.86 to 3.65) |
| − | − | + | 635 | 34 | 2534 | 13.4 | 4.10 (2.81 to 5.98)*** |
| + | + | − | 151 | 8 | 687 | 11.6 | 3.24 (1.58 to 6.62)** |
| − | + | + | 73 | 6 | 262 | 22.9 | 4.94 (2.17 to 11.2)*** |
| + | − | + | 469 | 24 | 2008 | 12.0 | 4.94 (3.21 to 7.60)*** |
| + | + | + | 32 | 4 | 116 | 34.6 | 8.64 (3.19 to 23.4)*** |
| Scrub typhus | COPD | CAD | |||||
| − | − | − | 20 184 | 178 | 105 873 | 1.68 | 1 (Reference) |
| + | − | − | 4883 | 61 | 25 293 | 2.41 | 1.50 (1.12 to 2.01)** |
| − | + | − | 217 | 5 | 888 | 5.63 | 1.07 (0.44 to 2.61) |
| − | − | + | 381 | 17 | 1637 | 10.4 | 2.32 (1.40 to 3.84)** |
| + | + | − | 150 | 9 | 692 | 13.0 | 3.33 (1.70 to 6.54)*** |
| − | + | + | 78 | 9 | 263 | 34.2 | 5.12 (2.59 to 10.1)*** |
| + | − | + | 149 | 10 | 644 | 15.5 | 4.46 (2.35 to 8.45)*** |
| + | + | + | 33 | 3 | 111 | 27.0 | 5.27 (1.67 to 16.6)*** |
N: sample size; n: events of ACS.
*p< 0.05, **p<0.01, ***p<0.001.
‡Ratex: incidence rate, per 1000 person-years.
‡Adjusted HR: multivariable analysis including age, and sex.
ACS, acute coronary syndrome; CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; PY, person-years.