Table 3

Cox proportional hazard analysis for the prediction of clinical events in 435 patients with LGSAS

Univariable analysisMultivariable analysis
HR95% CIp ValueHR95% CIp Value
(A) Aortic valve events
 Age1.1150.971 to 1.2810.12
 Female0.7570.578 to 0.9920.04
 Height1.1771.030 to 1.3440.02
 Weight1.1050.970 to 1.2580.14
 Hypertension0.9830.732 to 1.3200.91
 History of CHD1.1020.841 to 1.4440.48
 Current smoker0.9300.656 to 1.3180.69
 Blood pressure systolic0.9320.815 to 1.0650.30
 Blood pressure diasystolic0.9660.843 to 1.1060.62
 Heart rate1.0790.943 to 1.2360.27
 Low density lipoprotein0.9170.801 to 1.0500.21
 Creatinine0.9990.872 to 1.1450.99
 Glucose1.0490.920 to 1.1960.49
 LV end-diastolic diameter1.1110.967 to 1.2760.46
 LVOT diameter0.9280.799 to 1.0860.17
 EF0.8520.742 to 0.9780.02
 LV mass index1.1761.040 to 1.329<0.001
 Jet velocity*1.5881.378 to 1.831<0.0011.4911.283 to 1.733<0.001
 MPG1.6211.412 to 1.860<0.0011.6211.412 to 1.860<0.001
 Aortic valve area0.8210.720 to 0.9370.003
 Aortic valve area index0.7730.676 to 0.885<0.001
 VR0.7180.622 to 0.830<0.0010.8320.714 to 0.9700.019
(B) Cardiovascular death
 Age2.9661.790 to 4.915<0.0012.9661.790 to 4.915<0.001
 Female0.9060.462 to 1.7780.77
 Height1.0140.723 to 1.4210.94
 Weight0.8250.574 to 1.1840.29
 Hypertension2.4261.160 to 5.0770.02
 History of CHD0.7320.329 to 1.6280.44
 Current smoker1.0370.429 to 2.5050.93
 Blood pressure systolic1.1820.858 to 1.6300.31
 Blood pressure diasystolic1.0840.771 to 1.5250.64
 Heart rate1.4371.058 to 1.9520.021.4421.059 to 1.0640.020
 Low-density lipoprotein0.8960.637 to 1.2610.53
 Creatinine1.3110.947 to 1.8150.10
 Glucose1.0160.710 to 1.4530.93
 LV end-diastolic diameter1.0660.760 to 1.4970.71
 LVOT diameter1.0330.738 to 1.4440.85
 EF0.5310.376 to 0.7490.0050.6340.434 to 0.9270.019
 LV mass index1.6221.242 to 2.118<0.0011.6001.230 to 2.080<0.001
 Jet velocity*0.7210.674 to 1.3140.72
 MPG1.1520.823 to 1.6130.41
 Aortic valve area0.8150.593 to 1.1210.21
 Aortic valve area index0.8880.636 to 1.2410.49
 VR0.7600.530 to 1.0910.14
(C) All-cause mortality
 Age2.4971.727 to 3.610<0.0012.5511.684 to 3.866<0.001
 Female0.6920.409 to 1.1700.17
 Height0.9960.765 to 1.2970.98
 Weight0.9180.701 to 1.2030.54
 Hypertension2.1251.213 to 3.7250.006
 History of CHD2.0201.016 to 4.0130.04
 Current smoker1.4450.654 to 3.1900.36
 Blood pressure systolic1.1430.888 to 1.4710.30
 Blood pressure diasystolic1.0840.831 to 1.4130.55
 Heart rate1.4841.173 to 1.8770.0011.3801.070 to 1.7820.013
 Low-density lipoprotein0.9080.696 to 1.1840.48
 Creatinine1.4621.147 to 1.8650.0031.3531.044 to 1.7520.022
 Glucose1.0090.761 to 1.3380.95
 LV end-diastolic diameter1.0150.779 to 1.3210.91
 LVOT diameter1.1100.860 to 1.4330.42
 EF0.7050.534 to 0.9300.013
 LV mass index1.3551.079 to 1.7020.0091.2791.003 to 1.6290.047
 Jet velocity*0.9800.755 to 1.2710.88
 MPG1.1390.877 to 1.4810.33
 Aortic valve area0.9310.720 to 1.2050.59
 Aortic valve area index0.9630.741 to 1.2510.78
 VR0.8360.635 to 1.1010.20
  • Univariable and multivariable Cox regression analysis for the association with clinical events in 435 patients with LGSAS. All variables significantly associated with clinical events in univariable analysis (p<0.05) were included in the multivariable model.

  • *Jet velocity demonstrated a strong colinearity with MPG (r=0.934). Multivariable models for aortic valve events were therefore run with either variable. VR remained associated with aortic valve events irrespective of which covariable was entered (see text for details).

  • CHD, coronary heart disease; LGSAS, low gradient severe aortic stenosis; MPG, mean pressure gradient; LVOT, LV outflow tract; VR, velocity ratio.