Baseline characteristics
| Overall n=442 | MT n=78 | SAVR n=107 | TAVI n=257 | p Value | |
|---|---|---|---|---|---|
| Age: median (IQR) | 83 (8) | 84 (7) | 80 (8) | 83 (7) | <0.001 |
| Women | 230 (52.0%) | 33 (42.3%) | 53 (49.5%) | 144 (56.0%) | 0.090 |
| BMI (kg/m2): mean (SD) | 25.6 (4.8) | 24.4 (3.5) | 26.0 (4.7) | 25.8 (5.1) | 0.030 |
| Cardiac risk factors | |||||
| Hypertension | 338 (76.5%) | 52 (66.7%) | 85 (79.4%) | 201 (78.2%) | 0.080 |
| Current smoker | 65 (14.7%) | 7 (9.0%) | 16 (15.0%) | 42 (16.3%) | 0.270 |
| Diabetes mellitus | 101 (22.9%) | 18 (23.1%) | 21 (19.6%) | 62 (24.1%) | 0.650 |
| Hypercholesterolaemia | 233 (52.7%) | 32 (41.0%) | 46 (43.0%) | 155 (60.3%) | 0.001 |
| Past medical history | |||||
| Prior MI | 79 (17.9%) | 23 (29.5%) | 9 (8.4%) | 47 (18.3%) | 0.001 |
| Prior PCI | 77 (17.4%) | 10 (12.8%) | 9 (8.4%) | 58 (22.6%) | 0.003 |
| CABG | 76 (17.2%) | 18 (23.1%) | 4 (3.7%) | 54 (21.0%) | <0.001 |
| Stroke | 44 (10.0%) | 13 (16.7%) | 8 (7.5%) | 23 (9.0%) | 0.080 |
| PVD | 93 (21.0%) | 16 (20.5%) | 13 (12.1%) | 64 (24.9%) | 0.030 |
| Symptoms | |||||
| NYHA III or IV | 251 (56.9%) | 48 (62.3%) | 48 (44.9%) | 155 (60.3%) | 0.014 |
| Angina | 157 (35.5%) | 27 (34.6%) | 55 (51.4%) | 75 (29.2%) | <0.001 |
| Syncope | 51 (11.5%) | 14 (18%) | 13 (12.1%) | 24 (9.3%) | 0.110 |
| Atrial fibrillation | 105 (23.8%) | 20 (25.6%) | 19 (17.8%) | 66 (25.7%) | 0.250 |
| Risk assessment | |||||
| Log. EuroSCORE: median (IQR) | 19.1 (19.9) | 25.8 (22.5) | 9.8 (8.2) | 22.4 (19.9) | <0.001 |
| Lin. EuroSCORE: median (IQR) | 10 (4) | 11 (2) | 8 (2) | 11 (3) | <0.001 |
| STS score: median (IQR) | 4.7 (3.6) | 5.4 (4.7) | 3.4 (2.7) | 5.1 (3.8) | <0.001 |
| Medications | |||||
| Acetylsalicylic acid | 254 (57.5%) | 39 (50.0%) | 59 (55.1%) | 156 (60.7%) | 0.210 |
| Clopidogrel | 62 (14.0%) | 10 (12.8%) | 5 (4.7%) | 47 (18.3%) | 0.003 |
| Oral anticoagulation | 114 (25.8%) | 22 (28.2%) | 18 (16.8%) | 74 (28.8%) | 0.050 |
BMI, body mass index; CABG, coronary artery bypass grafting; MI, myocardial infarction; MT, medical treatment; NYHA, New York Heart Association; PCI, percutaneous coronary intervention; PVD, peripheral vascular disease; SAVR, surgical aortic valve replacement, TAVI, transcatheter aortic valve implantation.