HRs for RHR variables and the risk of incident MI events and death
| Events | Subjects | Person-years | RHR mean, HR (95% CI) | RHR trend, HR (95% CI) | RHR variation, HR (95% CI) | |
|---|---|---|---|---|---|---|
| Any incident MI event | ||||||
| Minimally adjusted | 262 | 1991 | 22 372 | 1.07 (0.92 to 1.25) | 1.12 (0.99 to 1.28) | 1.01 (0.90 to 1.13) |
| CV risk factor-adjusted | 260 | 1971 | 22 173 | 1.00 (0.86 to 1.17) | 1.09 (0.96 to 1.24) | 1.03 (0.92 to 1.15) |
| Fully-adjusted | 259 | 1941 | 21 920 | 0.99 (0.85 to 1.16) | 1.08 (0.95 to 1.23) | 1.01 (0.90 to 1.14) |
| Death from any cause | ||||||
| Minimally-adjusted | 1326 | 1991 | 23 324 | 1.14 (1.07 to 1.22) | 0.98 (0.92 to 1.04) | 1.07 (1.03 to 1.13) |
| CV risk factor-adjusted | 1311 | 1971 | 23 122 | 1.12 (1.05 to 1.20) | 0.97 (0.91 to 1.03) | 1.08 (1.03 to 1.13) |
| Fully adjusted | 1286 | 1941 | 22 862 | 1.08 (1.01 to 1.16) | 0.98 (0.91 to 1.04) | 1.06 (1.02 to 1.12) |
Each regression model included all three RHR exposure variables and HRs adjusted for cardiovascular risk factors represent the primary analyses (bolded). HRs for RHR mean, RHR trend and RHR variation are per units of 10 bpm, 2 bpm/year and 2 bpm, respectively. Minimally adjusted models were adjusted for age, sex and race; CV risk factor-adjusted models were also adjusted for current smoking, treated diabetes mellitus, systolic blood pressure, high-density lipoprotein cholesterol level and the presence of subclinical cardiovascular disease; and fully adjusted models were also adjusted for marital status, education, self-reported health status, regular moderate or high-intensity exercise, body mass index, serum creatinine, 15-foot walk speed and grip strength.
CV, cardiovascular; MI, myocardial infarction; RHR, resting heart rate.