Diastolic parameters of Fabry cohort by echocardiography
| Post-treatment | Baseline | Year 1 | Year 2 | Year 5 | Year 7 | Year 10 |
|---|---|---|---|---|---|---|
| DT (ms) | ||||||
| Non-CKD5 | 216±21 | 214±33 | 211±33 | 198±37 | 215±35 | 219±33 |
| CKD5 | 264±81 | 274±81 | 251±69 | 258±80 | 260±64 | 315±161 |
| IVRT (ms) | ||||||
| Non-CKD5 | 92±18 | 85±10 | 83±14 | 80±12 | 93±11 | 86±13 |
| CKD5 | 99±16 | 101±15 | 99±23 | 114±22 | 105±35 | 101±14 |
| E/A | ||||||
| Non-CKD5 | 1.66±0.59 | 1.88±0.89 | 1.89±0.80 | 1.71±0.57 | 1.73±0.77 | 1.40±0.41 |
| CKD5 | 1.12±0.29 | 1.06±0.17 | 1.32±0.28 | 1.27±0.27 | 1.03±0.24 | 1.29±0.38 |
| E/Ea | ||||||
| Non-CKD5 | 10.8±6.0 | 10.6±5.5 | 10.3±4.2 | 11.1±3.6 | 10.4±3.4 | 10.2±3.2 |
| CKD5 | 15.7±8.7 | 15.8±8.7 | 16.1±9.3 | 15.8±8.3 | 21.8±12.9 | 21.2±8.2 |
Non-CKD5 cohort size: baseline (N=15), year 1 (N=15), year 2 (N=15), year 5 (N=12), year 7 (N=12) and year 10 (N=12).
CKD5 cohort size: baseline (N=10), year 1 (N=9), year 2 (N=10), year 5 (N=6), year 7 (N=6) and year 10 (N=5).
Two-way ANOVA comparing CKD5 with non-CKD5 for parameters DT, IVRT, E/A and E/Ea over the duration of treatment were all statistically different (p<0.0001).
ANOVA, analysis of variance; CKD5, chronic kidney disease stage 5; DT, deceleration time; E/Ea, estimated LV filling pressure; IVRT, isovolumetric relaxation time.