Genotype–phenotype associations for non-sarcomeric protein genes not meeting the predefined statistical thresholds for multiple testing
| Phenotype | Gene | Frequency or mean±SD—Variant present | Frequency or mean±SD—Variant absent | p Value |
|---|---|---|---|---|
| LA diameter at last follow-up (mm) | SCN5A | 46.9±5.4 | 44.3±7.5 | 0.04 |
| LVOTO (>30 mm Hg) | SCN5A | 57.5% (23/40) | 39.5% (305/772) | 0.03 |
| Ion-channel | 49.2% (89/181) | 37.9% (239/631) | 0.006 | |
| MLVWT (mm) | ANK2 | 19.7±5.6 | 18.4±4.2 | 0.02 |
| E/e′ ratio | CASQ2 | 16.4±7.1 | 11.4±5.9 | 0.02 |
| NSVT | PLN | 100% (3/3) | 22.1% (124/562) | 0.01 |
p Values reflect the comparison for proportions or means between patients with and without a rare variant in a given gene.
E to é ratio, ratio between the maximal velocity of the E wave from the pulsed wave Doppler of the transmitral flow and the maximal velocity of the e′ wave of tissue Doppler at the mitral annulus; LA, left atria; LVOTO, LV outflow tract obstruction; MLVWT, maximal LV wall thickness; NSVT, non-sustained ventricular tachycardia.