In-hospital clinical outcomes and cumulative mortality in terms of preoperative renal function
| CKD stage 1–2 | CKD stage 3a | CKD stage 3b | CKD stage 4 | CKD stage 5 | ||
|---|---|---|---|---|---|---|
| eGFR (mL/min/1.73 m2) | >60 (n=1390) | 45–59 (n=1046) | 30–44 (n=846) | 15–29 (n=315) | <15 or dialysis (n=99) | p Value for trend |
| In-hospital outcomes | ||||||
| Death | 66 (4.7) | 46 (4.4) | 58 (6.9) | 27 (8.6) | 8 (8.1) | 0.001 |
| Myocardial infarction | 9 (0.6) | 12 (1.1) | 8 (0.9) | 2 (0.63) | 0 (0) | 0.9 |
| Cardiac tamponade | 23 (1.7) | 19 (1.8) | 14 (1.7) | 12 (3.8) | 2 (2.0) | 0.1 |
| Stroke | 36 (2.6) | 23 (2.2) | 19 (2.2) | 15 (4.8) | 3 (3.0) | 0.3 |
| Gastrointestinal bleed | 16 (1.2) | 6 (0.6) | 7 (0.8) | 4 (1.3) | 5 (5.1) | 0.1 |
| Platelet transfusion | 39 (2.8) | 22 (2.1) | 27 (3.2) | 8 (2.5) | 7 (7.1) | 0.2 |
| New need for dialysis | 21 (1.5) | 31 (3.0) | 51 (6.0) | 40 (12.7) | 6 (33)* | <0.001 |
| Vascular complication needing surgery | 27 (1.9) | 18 (1.7) | 21 (2.5) | 5 (1.6) | 2 (2.0) | 0.8 |
| Cumulative mortality | ||||||
| Overall mortality | 372 (26.8) [n=1390] | 292 (27.9) [n=1046] | 287 (33.9) [n=846] | 130 (41.2) [n=315] | 38 (38.4) [n=99] | <0.001 |
| Mortality at 1 year post-procedure | 196 (17.2) [n=1136] | 155 (17.5) [n=886] | 154 (21.8) [n=708] | 75 (28.0) [n=268] | 28 (39.4) [n=71] | <0.001 |
| Mortality at 2 years post-procedure | 262 (34.3) [n=764] | 220 (35.5) [n=620] | 207 (40.8) [n=507] | 96 (47.3) [n=203] | 32 (61.5) [n=52] | <0.001 |
| Mortality at 3 years post-procedure | 305 (54.2) [n=563] | 259 (55.1) [n=470] | 251 (62.1) [n=404] | 113 (62.8) [n=180] | 38 (86.4) [n=44] | <0.001 |
*Eighteen patients not on dialysis before transaortic valve implantation.
Categorical values are summarised by count (percentage).
CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate.