Cox regression univariable and multivariable associations with cumulative mortality
| Univariate analysis | Multivariate analysis* | |||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| CKD stages 1–2 | 1.0 | 1.0 | ||
| CKD stage 3a | 1.05 (0.90 to 1.22) | 0.6 | 1.02 (0.86 to 1.20) | 0.8 |
| CKD stage 3b | 1.33 (1.14 to 1.55) | <0.001 | 1.27 (1.08 to 1.50) | 0.004 |
| CKD stage 4 | 1.60 (1.31 to 1.96) | <0.001 | 1.41 (1.14 to 1.75) | 0.002 |
| CKD stage 5 | 2.01 (1.44 to 2.80) | <0.001 | 2.06 (1.42 to 2.98) | <0.001 |
| Moderate-advanced CKD (stages 3b–5) | 1.44 (1.25 to 1.66) | <0.001 | 1.36 (1.17 to 1.58) | <0.001 |
| Moderate-advanced CKD (stages 3b–5) excluding dialysis | 1.41 (1.23 to 1.63) | <0.001 | 1.32 (1.13 to 1.54) | <0.001 |
| Advanced CKD (stages 4–5) | 1.68 (1.40 to 2.02) | <0.001 | 1.41 (1.13 to 1.64) | <0.001 |
| Advanced CKD (stages 4–5) excluding dialysis | 1.63 (1.34 to 1.99) | <0.001 | 1.33 (1.13 to 1.66) | 0.001 |
| eGFR as a continuous variable (mL/min/1.73 m2)† | 0.99 (0.99 to 1.00) | <0.001 | 1.00 (0.99 to 1.00) | 0.007 |
*Adjusted for age, gender, body mass index, smoking status, diabetes mellitus, previous myocardial infarction, coronary artery stenosis >50%, New York Heart Association functional class, known chronic obstructive pulmonary disease, previous stroke, extracardiac arteriopathy, ascending aortic calcification, pre-existing atrial fibrillation, previous cardiac surgery, LVEF <30%, aortic valve gradient, aortic valve area, procedure urgency, non-transfemoral approach and successful valve deployment.
†Patients on dialysis excluded.
CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate.