Predictive factors of late death
| Unadjusted HR (95% CI) | p Value | Adjusted HR (95% CI) | p Value | |
|---|---|---|---|---|
| Preprocedure | ||||
| Age (years) | 1.09 (0.83 to 1.44) | 0.60 | ||
| Male gender | 1.50 (0.94 to 2.39) | 0.09 | ||
| Body mass index (kg/m2) | 1.00 (0.96 to 1.05) | 0.92 | ||
| Previous cardiac surgery | 1.07 (0.65 to 1.76) | 0.79 | ||
| Previous cerebrovascular accident | 0.75 (0.34 to 1.65) | 0.48 | ||
| Lower limb arteritis | 1.98 (1.12 to 3.50) | 0.02 | 2.18 (1.21 to 3.91) | 0.009 |
| Peripheral artery disease | 1.28 (0.79 to 2.09) | 0.31 | ||
| Respiratory insufficiency | 1.26 (0.78 to 2.04) | 0.34 | ||
| Dialysis | 0.89 (0.22 to 3.62) | 0.87 | ||
| Cancer | 1.27 (0.80 to 2.04) | 0.31 | ||
| Chest radiation therapy | 1.47 (0.75 to 2.88) | 0.27 | ||
| Charlson comorbidity index (per 1-unit increase) | 1.14 (1.03 to 1.26) | 0.01 | 1.12 (1.01 to 1.24) | 0.03 |
| Smoking | 1.29 (0.81 to 2.05) | 0.28 | ||
| Hypertension | 0.70 (0.43 to 1.14) | 0.16 | ||
| Diabetes | 1.71 (1.03 to 2.84) | 0.04 | ||
| Dyslipidemia | 0.86 (0.55 to 1.35) | 0.50 | ||
| NYHA class (III–IV vs II) | 1.61 (0.74 to 3.51) | 0.23 | ||
| CCS class (4 vs ≤3) | 1.24 (0.87 to 1.77) | 0.23 | ||
| Syncope | 1.46 (0.83 to 2.58) | 0.19 | ||
| Atrial fibrillation | 1.53 (0.97 to 2.41) | 0.07 | ||
| Indexed aortic valve area (cm2/m2) | 8.49 (0.65 to 10.45) | 0.10 | ||
| Mean aortic gradient (mm Hg) | 0.99 (0.97 to 1.01) | 0.20 | ||
| LVEF (%) | 1.00 (0.99 to 1.02) | 0.65 | ||
| Systolic PAP (mm Hg) | 0.94 (0.79 to 1.11) | 0.45 | ||
| AR ≥2/4 | 1.30 (0.67 to 2.53) | 0.44 | ||
| MR ≥2/4 | 1.41 (0.80 to 2.48) | 0.24 | ||
| Coronary artery disease (≥50% stenosis) | 1.02 (0.64 to 1.62) | 0.92 | ||
| Haemoglobin (g/dL) | 1.12 {0.98 to 1.29) | 0.09 | ||
| Creatinine (µmol/L) | 1.03 (1.01 to 1.05) | 0.01 | ||
| Procedure | ||||
| Access (other vs femoral) | 1.23 (0.76 to 1.97) | 0.40 | ||
| Type of prosthesis (CoreValve vs Edwards) | 1.12 (0.51 to 2.45) | 0.77 | ||
| Postprocedure | ||||
| Severe vascular complications | 0.66 (0.33 to 1.32) | 0.24 | ||
| Severe bleeding | 0.83 (0.36 to 1.90) | 0.65 | ||
| Stroke/TIA | 1.13 (0.35 to 3.58) | 0.84 | ||
| Echography at day 7 | ||||
| Paraprosthetic AR ≥2/4 | 2.13 (1.05 to 4.29) | 0.04 | 2.56 (1.25 to 5.24) | 0.01 |
| MR ≥2/4 | 1.40 (0.70 to 2.79) | 0.34 | ||
| Mean aortic gradient (mm Hg) | 0.95 (0.88 to 1.01) | 0.10 | ||
| Systolic PAP (mm Hg) | 1.02 (1.00 to 1.04) | 0.04 | ||
Univariate and multivariate analyses.
AR, aortic regurgitation; CCS, Canadian Cardiovascular Society; MR, mitral regurgitation; NYHA, New York Heart Association; PAP, pulmonary artery pressure; TIA, transient ischaemic attack.