Univariable and multivariable analyses of predictors of late mortality
| Univariable analysis | Multivariable model #1 | Multivariable model #2 | ||||
|---|---|---|---|---|---|---|
| Variables | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value |
| Clinical data | ||||||
| Age (per 1-year increase) | 1.00 (0.98 to 1.03) | 0.7 | – | – | – | – |
| Male gender | 1.84 (1.20 to 2.82) | 0.005 | 1.93 (1.20 to 3.09) | 0.006 | 1.94 (1.20 to 3.15) | 0.007 |
| Permanent atrial fibrillation/flutter | 2.08 (1.32 to 3.22) | 0.001 | 1.85 (1.15 to 2.98) | 0.01 | 1.86 (1.15 to 3.02) | 0.01 |
| Estimated GFR (per 10 mL/min decrease) | 1.11 (0.99 to 1.25) | 0.08 | – | – | – | – |
| Transapical approach | 1.78 (1.06 to 2.97) | 0.03 | 1.91 (1.06 to 3.41) | 0.03 | 1.91 (1.07 to 3.42) | 0.03 |
| ln EuroSCORE (per 1% increase) | 1.46 (1.07 to 1.99) | 0.02 | – | – | – | – |
| ln STS score (per 1% increase) | 1.53 (1.04 to 2.26) | 0.03 | – | – | – | – |
| Baseline echocardiographic data | ||||||
| B-LVEF (per 10% decrease) | 1.16 (1.01 to 1.33) | 0.04 | – | – | – | – |
| B-mean gradient (per 10 mm Hg decrease) | 1.33 (1.13 to 1.56) | 0.001 | – | – | – | – |
| B-SVi (per 10 mL/m2 decrease) | 1.41 (1.08 to 1.85) | 0.01 | – | – | 1.02 (0.75 to 1.39) | 0.9 |
| B-aortic valve area (per 0.1 cm2 decrease) | 1.13 (0.99 to 1.29) | 0.07 | – | – | – | – |
| B-moderate or severe MR | 1.68 (1.03 to 2.76) | 0.04 | – | – | – | – |
| B-indexed end-diastolic diameter (per 1 mm/m2 increase) | 1.03 (0.99 to 1.06) | 0.08 | – | – | – | – |
| Early postprocedural echocardiographic data | ||||||
| EP-LVEF (per 10% decrease) | 1.28 (1.11 to 1.48) | 0.001 | 1.02 (0.85 to 1.22) | 0.8 | 1.02 (0.85 to 1.21) | 0.8 |
| EP-mean gradient (per 10 mm Hg decrease) | 2.06 (1.17 to 3.63) | 0.01 | 1.61 (0.90 to 2.88) | 0.11 | 1.61 (0.90 to 2.89) | 0.11 |
| EP-SVi (per 10 mL/m2 decrease) | 1.77 (1.31 to 2.40) | <0.001 | 1.41 (1.03 to 1.93) | 0.03 | 1.42 (1.01 to 2.01) | 0.047 |
| EP-moderate or severe AR | 2.30 (1.05 to 5.01) | 0.04 | 4.68 (1.93 to 11.36) | 0.001 | 4.68 (1.93 to 11.37) | 0.001 |
| EP-moderate or severe MR | 2.27 (1.35 to 3.81) | 0.002 | 2.03 (1.13 to 3.66) | 0.02 | 2.02 (1.12 to 3.65) | 0.02 |
| EP-pulmonary hypertension | 1.65 (1.06 to 2.58) | 0.028 | 1.13 (0.68 to 1.89) | 0.6 | 2.03 (0.68 to 1.89) | 0.6 |
| EP-indexed end-diastolic diameter (per 1 mm/m2 increase) | 1.03 (0.99-1.06) | 0.071 | – | – | – | – |
Multivariable model #2 includes the same variables as model #1 plus baseline SVi.
AR, aortic regurgitation; B, baseline; EP, early postprocedural; EuroSCORE, European System for Cardiac Operative Risk Evaluation; GFR, glomerular filtration rate; MR, mitral regurgitation; STS, Society of Thoracic Surgeons; SVi, stroke volume index.