Changes in mitral regurgitation severity following TAVR
| First author, year (ref.) | Sample size | ≥Moderate MR | Prosthesis type | Improved n (%) | Same n (%) | Worsened n (%) | p Value |
|---|---|---|---|---|---|---|---|
| Tzikas, 201021 | 79 (46)* | 10 | SEV | 8 (17.4)* | 28 (60.9)* | 10 (10.3)* | |
| Gotzmann, 201022 | 39 | 19 | SEV | 7 (17.9) | 23 (59.0) | 9 (9.3) | |
| De Chiara, 201123 | 58 | 16 | SEV | 2 (3.4) | 47 (81.0) | 9 (15.5) | |
| Samin, 201124 | 18 | 6 | BEV | 7 (38.9) | 11 (61.1) | 0 (0) | |
| Hekimian, 201225 | 99 | 33 | BEV | 28 (28.3) | 60 (60.6) | 11 (11.1) | |
| Toggweiler, 201226 | 451 | 132 (123)† | BEV | 81 (65.9)† | 38 (30.9)† | 4 (3.3)† | |
| Hutter, 201327 | 268 | 60 (31)‡ | Both | 21 (67.7)‡ | 9 (29.0)‡ | 1 (3.2)‡ | |
| Giordana, 201328 | 35 | 35 | Both | 25 (71.4) | 10 (28.6) | 0 (0) | |
| Bedgoni, 20139 | 829 | 261 | SEV | 108 (13.0) | 668 (80.6) | 53 (6.4) | |
| Pooled data for all patients | |||||||
| SEV | 1005 | 144 (14.3) | 779 (77.5) | 82 (8.2) | <0.001 | ||
| BEV | 270 | 141 (52.2) | 114 (42.2) | 15 (5.6) | <0.001 | ||
| Overall | 1278 | 287 (22.5) | 894 (70.0) | 97 (7.6) | <0.001 | ||
| Pooled data for patients with ≥moderate MR | |||||||
| SEV | 326 | 133 (40.8) | 185 (56.7) | 8 (2.5) | <0.001 | ||
| BEV | 192 | 128 (66.7) | 60 (31.3) | 4 (2.1) | <0.001 | ||
| Overall | 521 | 263 (50.5) | 246 (47.2) | 12 (2.3) | <0.001 | ||
*Calculated for 46 patients with available echocardiographic data at follow-up.
†Calculated for 123 patients with ≥moderate MR and echocardiographic follow-up at 1 year (9 patients with ≥moderate MR died in the follow-up).
‡Calculated for 31 patients with ≥moderate MR and echocardiographic follow-up at 6 months (19 patients died and 10 patients did not have an echocardiogram at 6-month follow-up).
BEV, balloon-expandable valve; MR, mitral regurgitation; SEV, self-expandable valve; TAVR, transcatheter aortic valve replacement.