Table 4

Factors to be taken into account in future studies on prevention of reperfusion injury in patients with STEMI undergoing primary PCI

Pivotal factorsFactors of uncertaintyFactors with minimal impact
  • Include pre-PCI TIMI 0/1

  • Measure infarct size

  • Measure area at risk

  • Commence treatment prior to reperfusion

  • Focus on early presenters (eg, duration of symptoms <6 h and time from first medical contact to PCI <3 h)

  • Reduce dropout rates

  • Report dropouts and screen-log

  • Exclude preinfarction angina

  • Exclude patients with multivessel disease

  • Exclude patients with angiographic visible collaterals

  • Exclude patients with non-anterior infarction

  • Focus on patients with hyperglycaemia

  • PCI, percutaneous coronary intervention; STEMI, ST-segment elevation myocardial infarction; TIMI, thrombolysis in myocardial infarction.