Table 3

Cox proportional hazards regression for homograft dysfunction

HR95% CIp ValueHR95% CIp Value
Patient and surgical characteristics
 Age at PVR (per year)0.960.93 to 0.990.03
 Age at PVR <18 years2.531.27 to 5.030.0083.521.64 to 7.530.001
 Era PVR (per year)0.930.87 to 0.990.020.940.87 to 1.020.13
 Aortic homograft (vs pulmonary)2.520.82 to 7.780.11
 Diameter homograft (per mm)0.910.76 to 1.080.28
Preoperative echocardiography
 PS max gradient (per mm Hg)1.010.99 to 1.020.35
 PR grade (per grade)1.110.69 to 1.770.67
 TR grade (per grade)1.370.77 to 2.430.29
 Estimated PAP (per mm Hg)1.010.98 to 1.040.51
Postoperative echocardiography
 PS max gradient (per mm Hg)1.041.03 to 1.05<0.001
 PS max gradient ≥20 mm Hg5.432.64 to 11.1<0.0016.523.09 to 13.7<0.001
 PR grade (per grade)2.891.77 to 4.74<0.001
 PR grade ≥13.401.58 to 7.310.0023.131.45 to 6.740.004
 TR grade (per grade)1.440.72 to 2.880.31
 Estimated PAP (per mm Hg)1.000.94 to 1.040.96
Preoperative CMR
 RV EF (per %)1.030.97 to 1.090.35
 LV EF (per %)1.020.97 to 1.060.50
 RV EDVI (per mL/m2)1.000.98 to 1.010.40
 LV EDVI (per mL/m2)1.010.99 to 1.030.63
 PR fraction (per %)1.000.97 to 1.040.88
  • Univariate and multivariable predictors for homograft dysfunction (pulmonary stenosis ≥36 mm Hg or moderate PR).

  • CMR, cardiovascular magnetic resonance; EDVI, end-diastolic volume index; PAP, pulmonary artery pressure; PR, pulmonary regurgitation; PS, pulmonary stenosis; PVR, pulmonary valve replacement; TR, tricuspid regurgitation.