Comparison of demographic, anatomic, electrocardiographic, and exercise characteristics between patients with and without disease progression
| Progression (n=76) | No progression (n=133) | Adjusted p value* | |
|---|---|---|---|
| Demographic and anatomic features | |||
| Median age at baseline CMR (years) | 22 (1–62) | 22 (3–62) | 0.32 |
| Gender, male | 45 (59%) | 67 (50%) | 0.42 |
| Diagnosis | |||
| TOF | 68 (89%) | 116 (87%) | 0.50 |
| TOF, pulmonary atresia | 8 (11%) | 17 (13%) | – |
| Additional cardiovascular anomalies | 33 (43%) | 48 (36%) | 0.58 |
| Non-cardiac anomalies | 25 (33%) | 32 (24%) | 0.15 |
| Associated genetic disorder | 2 (3%) | 1 (1%) | 0.32 |
| Type of TOF repair | |||
| Transannular patch | 35 (46%) | 78 (59%) | – |
| RV-to-PA conduit | 9 (12%) | 11 (8%) | 0.55 |
| Other | 32 (42%) | 44 (33%) | 0.25 |
| ECG characteristics | |||
| Heart rate (bpm) | 76±17 | 73±13 | 0.13 |
| QRS duration (ms) | 143±28 | 140±30 | 0.59 |
| Exercise parameters at baseline CMR | |||
| Peak work rate | 123±39 | 130±45 | 0.57 |
| Peak VO2 (mL VO2/kg/min) | 28±10 | 25±8 | 0.29 |
| VAT (mL O2/kg/min) | 15±7 | 16±6 | 0.67 |
| Per cent predicted peak VO2 | 74±22 | 75±16 | 0.82 |
*p Values were adjusted for length of follow-up between CMR studies and account for the correlation of multiple CMR intervals within the same patient.
CMR, cardiac magnetic resonance; PA, pulmonary artery; TOF, tetralogy of Fallot.