Table 2

Subgroup-specific treatment effects predicted by multivariate adjusted network meta-analysis

GenderAgeQRSLBBBCRT-D vs MTCRT-P vs MTICD vs MTCRT-D vs CRT-PCRT-D vs ICDICD vs CRT-P
HR (95% CI)
Female<60<120N0.82 (0.60 to 1.13)
≥120 to <150N0.62 (0.40 to 0.96)0.86 (0.50 to 1.48)0.69 (0.48 to 0.99)0.72 (0.40 to 1.30)0.90 (0.58 to 1.39)0.80 (0.46 to 1.39)
≥120 to <150Y0.55 (0.36 to 0.84)0.76 (0.46 to 1.25)0.74 (0.51 to 1.07)0.72 (0.42 to 1.25)0.74 (0.48 to 1.13)0.98 (0.58 to 1.64)
≥150N0.55 (0.35 to 0.86)0.74 (0.42 to 1.28)0.77 (0.52 to 1.13)0.74 (0.41 to 1.35)0.71 (0.46 to 1.12)1.04 (0.59 to 1.83)
≥150Y0.48 (0.33 to 0.72)0.65 (0.42 to 1.00)0.82 (0.59 to 1.15)0.75 (0.45 to 1.24)0.59 (0.40 to 0.87)1.27 (0.79 to 2.04)
≥60<120N1.01 (0.76 to 1.36)
≥120 to <150N0.60 (0.41 to 0.90)0.75 (0.46 to 1.21)0.85 (0.62 to 1.17)0.81 (0.48 to 1.37)0.71 (0.48 to 1.04)1.14 (0.70 to 1.87)
≥120 to <150Y0.53 (0.37 to 0.78)0.65 (0.42 to 1.02)0.91 (0.66 to 1.27)0.82 (0.51 to 1.32)0.59 (0.41 to 0.84)1.39 (0.89 to 2.20)
≥150N0.53 (0.35 to 0.80)0.64 (0.39 to 1.03)0.94 (0.66 to 1.34)0.84 (0.50 to 1.40)0.57 (0.38 to 0.84)1.48 (0.91 to 2.41)
≥150Y0.47 (0.34 to 0.66)0.56 (0.40 to 0.79)1.01 (0.76 to 1.35)0.84 (0.56 to 1.27)0.47 (0.34 to 0.64)1.81 (1.24 to 2.64)
Male<60<120N0.62 (0.48 to 0.79)
≥120 to <150N0.72 (0.51 to 1.01)1.07 (0.70 to 1.64)0.52 (0.39 to 0.69)0.67 (0.42 to 1.06)1.37 (0.98 to 1.92)0.49 (0.31 to 0.76)
≥120 to <150Y0.63 (0.44 to 0.91)0.94 (0.61 to 1.43)0.56 (0.40 to 0.78)0.68 (0.43 to 1.07)1.13 (0.80 to 1.61)0.60 (0.38 to 0.93)
≥150N0.63 (0.44 to 0.91)0.91 (0.58 to 1.42)0.58 (0.42 to 0.80)0.69 (0.43 to 1.12)1.10 (0.78 to 1.54)0.63 (0.40 to 1.00)
≥150Y0.56 (0.40 to 0.77)0.80 (0.56 to 1.14)0.62 (0.46 to 0.83)0.70 (0.46 to 1.06)0.90 (0.67 to 1.23)0.77 (0.52 to 1.15)
≥60<120N0.76 (0.62 to 0.94)
≥120 to <150N0.70 (0.53 to 0.92)0.92 (0.64 to 1.32)0.64 (0.51 to 0.81)0.76 (0.52 to 1.10)1.09 (0.85 to 1.39)0.70 (0.48 to 1.00)
≥120 to <150Y0.62 (0.46 to 0.83)0.81 (0.57 to 1.16)0.69 (0.52 to 0.91)0.76 (0.53 to 1.11)0.90 (0.69 to 1.16)0.85 (0.59 to 1.23)
≥150N0.62 (0.46 to 0.83)0.79 (0.55 to 1.12)0.71 (0.54 to 0.93)0.78 (0.54 to 1.13)0.87 (0.67 to 1.12)0.90 (0.63 to 1.30)
≥150Y0.54 (0.43 to 0.69)0.69 (0.55 to 0.87)0.76 (0.60 to 0.96)0.79 (0.59 to 1.05)0.72 (0.59 to 0.87)1.10 (0.83 to 1.46)
  • CRT-D, cardiac resynchronisation therapy pacemaker with defibrillation therapy; CRT-P, cardiac resynchronisation therapy pacemakers; ICD, implantable cardioverter defibrillators; LBBB, left bundle branch block; MT, medical therapy.